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. 2015 Oct 17;13:330. doi: 10.1186/s12967-015-0683-x

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© Tuo et al. 2015

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 6 — Histology of the Ccl2 ^−/− /Cx3cr1 ^−/− /rd8 mouse retina. Representative histological micrographs: fewer lesions in anti-LRP6 treated eyes, as shown by the reduced loss of photoreceptors and more organized retinal structure. Black arrows indicate degenerative photoreceptors in the OPL (top right panel). Red arrows show degeneration and atrophy of ONL and loss of IS/OS in mIgG-injected group (bottom right panel). Some Crb1-associated lesions in the OPL are also seen (asterisk, top left panel) (H&E, original magnification, ×200). GCL ganglion cell layer, IPL inner plexiform layer, INL inner nuclear layer, OPL outer plexiform layer, ONL outer nuclear layer, IS/OS inner segments/outer segments of photoreceptors