Table 2.
Results of the univariate and multivariate analyses of prognostic factors for OS
| Univariate analysis | Multivariate analysis | |||||
|---|---|---|---|---|---|---|
| Characteristic | MST (mos) | 5-yr OS (%) | p-value | HR | 95 % CI | p-value |
| Gender | 0.431 | |||||
| Male | 23 | 27.4 | ||||
| Female | 28 | 24.5 | ||||
| Age | 0.834 | |||||
| < 60 years | 24 | 26.5 | ||||
| ≥ 60 years | 21 | 27.6 | ||||
| Weight loss | 0.292 | 1.01 | 0.61–1.66 | 0.977 | ||
| < 5 % | 24 | 28.7 | ||||
| ≥ 5 % | 24 | 20.2 | ||||
| Smoking index | 0.399 | |||||
| ≤ 400 | 26 | 26.5 | ||||
| > 400 | 20 | 27.4 | ||||
| Pretreatment hemoglobin | 0.580 | |||||
| < 120 g/L | 35 | - | ||||
| ≥ 120 g/L | 24 | 26.8 | ||||
| Pretreatment KPS | 0.096 | 0.68 | 0.34–1.37 | 0.285 | ||
| < 80 | 16 | 9.1 | ||||
| ≥ 80 | 24 | 28.0 | ||||
| Stage | 0.303 | |||||
| IIIa | 27 | 31.1 | ||||
| IIIb | 23 | 24.9 | ||||
| Histology subtype | 0.848 | |||||
| SCC | 24 | 28.0 | ||||
| Non-SCC | 24 | 25.1 | ||||
| Pretreatment CEA | 0.076 | 0.67 | 0.45–0.99 | 0.047 | ||
| < 5 ng/ml | 27 | 30.9 | ||||
| ≥ 5 ng/ml | 23 | 18.3 | ||||
| Radiotherapy technique | 0.128 | 1.09 | 0.66–1.79 | 0.743 | ||
| 3D-CRT | 18 | 16.2 | ||||
| IMRT | 25 | 30.1 | ||||
| Radiotherapy dose | 0.014 | 0.66 | 0.42–1.04 | 0.071 | ||
| ≥ 60 Gy | 25 | 29.5 | ||||
| < 60 Gy | 19 | 14.9 | ||||
| Concurrent chemotherapy | ||||||
| EP | 27 | 29.8 | 0.365 | |||
| PC | 19 | 24.0 | ||||
| Others | 25 | - | ||||
| Treatment modality | .012 | 0.61 | 0.42–0.88 | 0.008 | ||
| CRT + CCT | 27 | 30.4 | ||||
| CRT | 16 | 22.5 | ||||
| Response | 0.035 | 0.62 | 0.40–0.97 | 0.036 | ||
| CR + PR | 24 | 29.7 | ||||
| SD | 21 | 10.6 | ||||