Table 2.
Top twenty up (positive fold change) and down-regulated (negative fold change) genes in CLL versus Normal B cells
| Up-regulated genes | Down-regulated genes | ||||||
|---|---|---|---|---|---|---|---|
| Genes | Description | Fold change | q-value | Genes | Description | Fold change | q-value |
| FSTL1 | follistatin-like 1 | 1360 ± 4372 | 0.0090 | SYN3 | synapsin III | −270 | 0.0039 |
| MMP9 | matrix metallopeptidase 9 (gelatinase B, 92 kDa) | 1060 ± 1501 | 0.0323 | DSP | desmoplakin | −179 | 0.0222 |
| FMOD | fibromodulin | 789 ± 1041 | 0.0008 | FBLN2 | fibulin 2 | −134 | 0.0074 |
| CXCL5 | chemokine (C-X-C motif) ligand 5 | 593 ± 1008 | 0.0043 | ENAM | enamelin | −117 | 0.0103 |
| ADTRP | androgen-dependent TFPI-regulating protein | 586 ± 485 | 0.0031 | HDC | histidine decarboxylase | −103 | 0.0270 |
| KSR2 | kinase suppressor of ras 2 | 528 ± 750 | 0.0232 | CD1A | CD1a molecule | −99 | 0.0311 |
| THBS1 | thrombospondin 1 | 506 ± 640 | 0.0008 | MYO1B | myosin IB | −73 | 0.0112 |
| TGFBR3 | transforming growth factor, beta receptor III | 459 ± 205 | 0.0392 | LOC100505738 | uncharacterized LOC100505738 or MIR4458 | −66 | 0.0008 |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | 423 ± 512 | 0.0191 | SLC45A3 | solute carrier family 45, member 3 | −47 | 0.0008 |
| IL8 | interleukin 8 | 411 ± 462 | 0.0015 | MMRN1 | multimerin 1 | −46 | 0.0090 |
| CD300E | CD300e molecule | 401 ± 650 | 0.0251 | PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | −45 | 0.0031 |
| PRF1 | perforin 1 (pore forming protein) | 388 ± 265 | 0.0106 | ZNF618 | zinc finger protein 618 | −44 | 0.0015 |
| GIMAP7 | GTPase, IMAP family member 7 | 324 ± 305 | 0.0323 | UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | −44 | 0.0083 |
| CTLA4 | cytotoxic T-lymphocyte-associated protein 4 | 276 ± 255 | 0.0025 | AHNAK2 | AHNAK nucleoprotein 2 | −44 | 0.0008 |
| CD8A | CD8a molecule | 274 ± 257 | 0.0173 | GATA2 | GATA binding protein 2 | −39 | 0.0121 |
| NRP1 | neuropilin 1 | 263 ± 475 | 0.0488 | PARM1 | prostate androgen-regulated mucin-like protein 1 | −39 | 0.0008 |
| SFTPB | surfactant protein B | 261 ± 477 | 0.0052 | CR1 | complement component (3b/4b) receptor 1 | −39 | 0.0008 |
| TNFRSF1A | tumor necrosis factor receptor superfamily, member 1A | 240 ± 140 | 0.0052 | CABYR | calcium binding tyrosine-(Y)-phosphorylation regulated | −39 | 0.0264 |
| HBB | hemoglobin, beta | 234 ± 553 | 0.0020 | LOC100506178 | uncharacterized LOC100506178 | −36 | 0.0209 |
| CYBRD1 | cytochrome b reductase 1 | 216 ± 254 | 0.0020 | FFAR1 | free fatty acid receptor 1 | −34 | 0.0224 |
(q value: adjusted p-value)