Table 1.
Major substrates of SCF ubiquitin ligases, Fbw7, β-TrCP, and SKP2
| SCF-Fbw7 | ||
| Notch | Cell proliferation signaling | [140–143] |
| c-Myc | Transcription factor | [140, 144, 145] |
| c-Jun | Kinase | [146] |
| Cyclin E | Cell cycle regulator | [26, 147] |
| Mcl-1 | Differentiation protein | [148] |
| SREBP | Transcription factor | [149] |
| PGC-1a | Transcription factor involved in energy metabolism | [150] |
| Nrf-1 | Transcription factor | [151] |
| TGIF | Transcriptional repressor of TGF-b | [152] |
| Aurora-A | Kinase and regulator of chromosome segregation | [153, 154] |
| SV40 T antigen | Viral oncogene | [155] |
| KLF5 | Transcription factor | [156] |
| mTor | Kinase | [157] |
| SCF-βTrCP | ||
| Gli2 | Transcription factor | [158, 159] |
| GLi3 | Transcription factor and mediator of SHH signaling | [160, 161] |
| B-catenin | Transcription factor and cell adhesion; mediator of Wnt signaling | [162–164] |
| IkBα | NFkB inhibitor | [163–166] |
| mdm2 | Ubiquitin ligase for p53 | [148] |
| Wee1 | Cell cycle regulator kinase | |
| Cdc25a | Phosphatase in cell cycle regulation | [167] |
| Rest | Gene suppressor and chromosome stabilizer | [133] |
| Nrf-2 | Transcription factor for antioxidant enzymes | [168] |
| Emi1 | Cell cycle regulator kinase | [167] |
| HIV-1 Vpu | Viral pseudosubstrate | [169] |
| Per1/2 | Circadian regulation | [170–172] |
| Snail | Neural crest regulation | [173] |
| DEPTOR | Autophagy inhibitor | [174] |
| Mcl-1 | Differentiation protein | [175] |
| SCF-SKP2 | ||
| p27 | Cell cycle regulator | [176, 177] |
| p21 | Cell cycle regulator | [178, 179] |
| E2F | Transcription factor | [180] |
| Akt | Protein kinase | [181] |
| FOX01 | Transcription factor | [182] |
| Brca2 | DNA repair | [183] |
| cyclin A | Cell cycle regulator | [184] |
| cyclin E | Cell cycle regulator | [185] |
| c-myc | Transcription factor | [186] |
| HPV Viral E7 | Viral oncogene | [187] |