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. 2015 Aug 12;34(20):2522–2536. doi: 10.15252/embj.201490583

Figure 5.

Figure 5

Notch activation induces antral gland fission
  • A–C H&E-stained paraffin sections from (A) control or (B) Lgr5; ROSANICD stomach 4 weeks post-vehicle or TX treatment, or from (C) 3-week-old wild-type mouse stomach. Scale bars: 50 μm. Black rectangles indicate antral glands undergoing fission.
  • D Quantification of gland fission events in control (Lgr5) and Lgr5; ROSANICD stomachs 1 or 4 weeks post-TX (mean ± SEM;n = 3–6 mice). ***P < 0.001 versus control using two-way ANOVA.
  • E–I Confocal microscopic analysis of isolated glands immunostained for E-cadherin (green) with DAPI (red), or Ki67 (red) with DAPI (blue).