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. 2015 Aug 12;34(20):2522–2536. doi: 10.15252/embj.201490583

Figure 8.

Figure 8

Notch-activated antral polyps exhibit increased stem and progenitor cell marker expression
  • A–C Paraffin sections from Lgr5; ROSANICD stomach 6–12 months post-TX were stained for (A) proliferation by EdU incorporation (red) or immunostained for (B) CD44 or (C) Sox9. DAPI (blue) was used as a nuclear counterstain. Scale bars: 100 μm.
  • D–F Immunohistochemical analysis of (D) surface mucous cells (Muc5ac), (E) deep mucous cells (TFF2) and (F) endocrine cells (Gastrin) in Lgr5; ROSANICD mice 6–12 months post-TX. Compare Fig4 for normal tissue staining. Scale bars: 100 μm.