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. Author manuscript; available in PMC: 2016 May 1.
Published in final edited form as: Acad Emerg Med. 2015 Apr 23;22(5):508–517. doi: 10.1111/acem.12657

Figure 4. Both cocaine and cocaethylene preferentially inhibit carnitine exchange in isolated mitochondria.

Figure 4

(A) Carnitine-acylcarnitine translocase (CACT)-dependent respiration in rat, interfibrillar cardiac mitochondria at baseline and in the presence of cocaine, cocaethylene, and the cocaine metabolites ecgonine and benzoylecgonine (all 1 mM concentration). Both cocaine and cocaethylene significantly depress respiration (* p < 0.05). All data points plotted with median line.

(B) Representative Dixon plot of cocaine-based inhibition of carnitine-dependent respiration. Cocaine produced a non-competitive inhibition of carnitine-dependent respiration.

(C) Representative Dixon plot of cocaethylene based inhibition of carnitine dependent respiration. Cocaethylene produced a non-competitive inhibition of carnitine dependent respiration.

(D) Inhibitory constants (Ki) of CACT for both cocaine and cocaethylene. All data points plotted with median line.