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. Author manuscript; available in PMC: 2016 Aug 18.
Published in final edited form as: Environ Mol Mutagen. 2015 Apr 17;56(5):419–436. doi: 10.1002/em.21943

Table I.

Structural Variation and Environmental Mutagenesis

Observations:

  1. CNV important for disease (genomic disorders) & evolution

  2. CNV de novo mutation rates ≫> SNV (single nucleotide variant)

Questions:

  1. Do current mutagenesis assays (e.g. Ames test) measure CNV formation?

  2. Can we design such an assay?

  3. Are we introducing compounds into our environment that induce CNV mutagenesis?

  4. What is the evolutionary ‘rheostat’ – SNV or CNV?