Fig. 1.
Structure of [18F]PARPi-FL and schematic for the automated synthesis: a structures of the fluorescent monomodal and 18F-labeled bimodal PARP1 targeted probes and b the synthesis of [18F]PARPi-FL is automated and performed in an 18F synthesis module. The upper panel shows the azeotropic distillation. The middle panel illustrates the fluorination/reaction step, followed by HPLC purification (lower panel).