Table 5.
Associations between log10 ΣDMAP, ΣDEAP, and ΣDAP in maternal urine collected at enrollment, 32-wk of pregnancy and delivery and birth outcomes, stratified by maternal PON1 phenotype
| PON1 phenotype | Birth lengtha (cm) | Birth weighta (g) | Head circumferencea (cm) | Gestation ageb (wk) | ||||
|---|---|---|---|---|---|---|---|---|
|
| ||||||||
| β (95% CI) | p | β (95% CI) | p | β (95% CI) | p | β (95% CI) | p | |
| log10 ΣDMAP at enrollment | ||||||||
| AA, AB (n=23) | −0.3 (−2.6, 2.0) | 0.81 | −90.65 (−480.4, 299.2) | 0.63 | −1.6 (−3.0, −0.1) | 0.04* | 0.5 (−0.6, 1.5) | 0.36 |
| BB (n=29) | 1.9 (−1.5, 5.4) | 0.26 | 490.9 (−76.7, 920.4) | 0.02* | 0.4 (−1.9, 2.7) | 0.71 | 1.0 (−2.8, 0.9) | 0.29 |
| log10 ΣDEAP at enrollment | ||||||||
| AA, AB (n=23) | −0.4 (−1.8, 1.1) | 0.61 | −219.7 (−441.8, 2.34) | 0.05* | −1.0 (−2.0, −0.1) | 0.03* | −0.2 (−0.9, 0.5) | 0.54 |
| BB (n=29) | 0.2 (−1.6, 2.1) | 0.80 | 37.5 (−194.2, 269.3) | 0.74 | 0.3 (−0.8, 1.4) | 0.53 | −0.2 (−1.2, 0.8) | 0.69 |
| log10 ΣDAP at enrollment | ||||||||
| AA, AB (n=23) | −1.1 (−2.8, 0.6) | 0.19 | −371.3 (−674.7, −67.93) | 0.02* | −1.8 (−3.0, −0.6) | <0.01* | −0.2 (−1.2, 0.8) | 0.68 |
| BB (n=29) | 1.0 (−1.4, 3.4) | 0.40 | 165.2 (−136.2, 466.6) | 0.27 | 0.1 (−1.4, 1.6) | 0.85 | −0.3 (−1.6, 1.1) | 0.68 |
| log10 ΣDMAP at 32-wk of pregnancy | ||||||||
| AA, AB (n=23) | 1.4 (−1.5, 4.4) | 0.33 | 164.2 (−319.0, 647.3) | 0.49 | −0.3 (−2.4, 1.8) | 0.74 | −0.3 (−1.6, 1.1) | 0.68 |
| BB (n=29) | 2.2 (−2.2, 6.7) | 0.31 | 28.9 (−280.3, 842.2) | 0.31 | −1.0 (−3.7, 1.7) | 0.46 | −0.1 (−2.6, 2.3) | 0.90 |
| log10 ΣDEAP at 32-wk of pregnancy | ||||||||
| AA, AB (n=23) | −0.7 (−2.2, 0.8) | 0.35 | −178.2 (−509.5, 153.0) | 0.27 | −1.1 (−2.1, −0.1) | 0.04* | 0.7 (−0.1, −1.4) | 0.06 |
| BB (n=29) | 0.2 (−1.7, 2.2) | 0.80 | 78.6 (−168.1, 325.2) | 0.52 | −0.6 (−1.8, 0.5) | 0.31 | −0.3 (−1.3, 2.3) | 0.51 |
| log10 ΣDAP at 32-wk of pregnancy | ||||||||
| AA, AB (n=23) | −0.2 (−3.0, 2.6) | 0.90 | −138.7 (−682.6, 405.1) | 0.60 | −2.6 (−4.4, −0.8) | 0.01* | 1.1 (−0.1, 2.4) | 0.08 |
| BB (n=29) | 0.9 (−2.1, 3.9) | 0.55 | 171.1 (−203.8, 546.1) | 0.36 | −1.1 (−2.8, 0.7) | 0.49 | −0.5 (−2.0, 1.0) | 0.49 |
| log10 ΣDMAP at delivery | ||||||||
| AA, AB (n=23) | −0.9 (−0.7, 2.4) | 0.25 | 76.9 (−214.0, 367.7) | 0.59 | 2 2.0E10 (−1.3, 1.4) | 0.98 | 0.1 (−0.7, 1.0) | 0.72 |
| BB (n=29) | −0.8 (−4.0, 2.5) | 0.63 | −94.3 (−500.4, 311.4) | 0.63 | −1.3 (−3.1, 0.4) | 0.12 | 0.4 (−1.3, 2.1) | 0.63 |
| log10 ΣDEAP at delivery | ||||||||
| AA, AB (n=23) | −0.2 (−1.6, 1.1) | 0.69 | −95.9(−341.8, 150.0) | 0.42 | −0.2 (−1.2, 0.8) | 0.66 | 0.6 (0.1, 1.2) | 0.04* |
| BB (n=29) | −0.4 (−2.3, 1.5) | 0.66 | 10.3 (−232.6, 253.2) | 0.93 | −0.4 (−1.6, 0.7) | 0.42 | 0.3 (−0.8, 1.3) | 0.58 |
| log10 ΣDAP at delivery | ||||||||
| AA, AB (n=23) | 0.4 (−1.4, 2.2) | 0.62 | −56.8 (−394.0, 280.6) | 0.73 | −0.3 (−1.7, 1.0) | 0.59 | 0.7 (−0.1, 1.5) | 0.07 |
| BB (n=29) | −0.6 (−5.3, 4.0) | 0.78 | −188.4 (−769.9, 393.0) | 0.51 | −1.1 (−3.8, 1.7) | 0.42 | 0.1 (−2.4, 2.7) | 0.93 |
*
p <0.05 shows the significant difference.
a
Models adjusted for maternal age, preprenancy BMI, weight gain and gestational age.
b
Models adjusted for maternal age, preprenancy BMI and weight gain.