Table 4.

Generalized linear mixed regression models of the association of temporal changes in plasma IL-2 concentrations (pg/mL) with an interquartile range-unit change in urinary inorganic arsenic plus methylated species (∑As) concentration (µg/L) during pregnancy by HEV seroconversion status.

	HEV seroconverter Interleukin 2 (IL-2)			Non-seroconverter Interleukin 2 (IL-2)

	N	Beta (95% CI)^a	p^a	N	Beta (95% CI)^a	p^a	p-interaction^b
IL-2 (1st TM, 3rd TM, 3 months PP)
∑As (1st TM)	120	0.46 (0.23, 0.68)	< 0.0001	120	−0.03 (−0.39, 0.34)	0.88	0.02
IL-2 (3rd TM & 3 months PP)
∑As (3rd TM)	80	0.18 (−0.03, 0.39)	0.09	78	0.04 (−0.21, 0.29)	0.78	0.38
∑As (Average)^c	80	0.35 (0.12, 0.58)	0.003	78	0.01 (−0.29, 0.31)	0.96	0.07

Note. TM = trimester. PP = postpartum. For IL-2 concentrations below the limit of detection, 1/2 the limit was imputed. CI = confidence interval. ∑As = inorganic arsenic plus methylated species.

Beta coefficient, 95% CI, and p derived from generalized linear mixed regression models with pregnant women's repeated IL-2 (pg/mL) measurements as dependent variable.

p-value derived from a 1 df likelihood ratio test of interaction between ∑As and seroconversion status in a generalized linear mixed model.

Average of 1st and 3rd TM urinary ∑As.