Table 2.
Odds ratio for having insulin and leptin levels above the 75th percentile at 5 years of age after prenatal exposure to POPs, according to sex. Faroese Cohort 1996–2001, (N=520)1.
| Girls (n=247) | Boys (n=273) | |||
|---|---|---|---|---|
| Insulin (ng/mL) | Leptin (ng/mL) | Insulin (ng/mL) | Leptin (ng/mL) | |
| POPs in quartiles |
Odds Ratio (95% CI) | |||
| PCBs | ||||
| 1 | 1.00 | 1.00 | 1.00 | 1.00 |
| 2 | 2.59 (0.99, 6.81) | 0.68 (0.29, 1.60) | 0.57 (0.25, 1.33) | 0.63 (0.28, 1.44) |
| 3 | 2.00 (0.74, 5.44) | 0.48 (0.20, 1.18) | 0.84 (0.38, 1.87) | 1.20 (0.55, 2.59) |
| 4 | 3.74 (1.36, 10.27) | 0.61 (0.24, 1.53) | 1.13 (0.51, 2.48) | 0.78 (0.34, 1.79) |
| P for trend | 0.03 | 0.23 | 0.56 | 0.93 |
| DDE | ||||
| 1 | 1.0 | 1.0 | 1.0 | 1.0 |
| 2 | 2.02 (0.83, 4.93) | 0.99 (0.44, 2.22) | 1.12 (0.51, 2.48) | 0.87 (0.39, 1.94) |
| 3 | 0.99 (0.37, 2.64) | 0.46 (0.18, 1.14) | 0.75 (0.32, 1.72) | 1.00 (0.45, 2.20) |
| 4 | 2.74 (1.08, 6.94) | 0.75 (0.31, 1.82) | 1.56 (0.71, 3.44) | 1.01 (0.45, 2.28) |
| P for trend | 0.10 | 0.29 | 0.44 | 0.91 |
| HCB | ||||
| 1 | 1.0 | 1.0 | 1.0 | 1.0 |
| 2 | 1.24 (0.68, 2.24) | 0.58 (0.29, 1.15) | 0.98 (0.58, 1.65) | 0.97 (0.53, 1.77) |
| 3 | 1.13 (0.62, 2.06) | 0.57 (0.29, 1.13) | 1.04 (0.62, 1.76) | 1.11 (0.60, 2.06) |
| 4 | 1.86 (0.99, 3.47) | 0.68 (0.34, 1.36) | 1.36 (0.80, 2.30) | 1.25 (0.67, 2.36) |
| P for trend | 0.09 | 0.34 | 0.24 | 0.44 |
1
PCB and DDE concentration in maternal serum, µg/g lipid (log-transformed); The PCB concentration was based on the sum of PCB congeners 138, 153, and 180. HCB in maternal milk, µg/g lipid (log-transformed). Non-fasting serum concentrations of insulin and leptin (ng/mL) measured at 5 years of age. Logistic regression, adjustments made for maternal age, parity, maternal pre-pregnancy BMI, BMI at 5 years of age and time of day for blood sampling. PCBs, polychlorinated biphenyl(s); DDE, dichlorodiphenyldichloroethylene; HCB, hexachlorobenzene.