Table 2.

Associations between PAH/Aromatic (³²P)-DNA Adducts, BDNF, and MDI at 24 months¹

		Adducts and MDI			Adducts and BDNF5			BDNF and MDI			Adducts on MDI (BDNF in model)
PAH-DNA (32P) adducts		N	β adduct	P-value	N	β adduct	P-value	N	β BDNF	P-value	N	β adduct	P-value
MDI continuous	Unrestricted analysis3	380	−2.07	0.04 *	450	−0.11	0.02	386	2.69	0.003 *	345	−1.92	0.07
	Restricted analysis4	345	−2.10	0.05 *	345	−0.09	0.13	345	2.54	0.01 *
		N	OR	P-value				N	OR	P-Value	N	OR	P-value
MDI dichotomous2 (Odds Ratio, > 85 vs. <85)	Unrestricted analysis3	380	0.65	0.02 *				386	1.58	0.01 *	345	0.72	0.10
	Restricted analysis4	345	0.71	0.08				345	1.53	0.02 *

¹Adjusting for prenatal ETS, child sex, maternal education, child ethnicity, gestational age, quality of the postnatal caretaking environment (HOME), maternal intelligence, child age at assessment, and maternal demoralization. In analysis of the association between adducts and BDNF (both measured in cord blood), age at MDI assessment and HOME were not included.

²MDI scores were dichotomized at 85 (< 85 vs. > 85), the cutpoint for moderate developmental delay. MDI score >85 was coded as 1 and <85 as 0 such that an OR <1 implies a lower odds of being categorized as normal.

³Unrestricted analysis: including all subjects with any two measures (adducts, MDI, or BDNF)

⁴Restricted analysis: including subjects with all three measures (adducts, MDI, or BDNF)

⁵The results for the unrestricted and restricted analyses only appear once as the MDI score is not included in this analysis.

^*p-value <0.05