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Synthesis and testing of MN-anti-miR10b. a. MN-anti-miR10b consisted of dextran-coated magnetic nanoparticles conjugated to an antisense LNA oligonucleotide targeting miRNA-10b. b. qRT-PCR showed significant inhibition of miRNA-10b, following a 48-hr incubation of human metastatic breast cancer cells with MN-anti-miR10b (Data represent average±s.d.; two-tailed t-test; n = 3).
