Table 2.
Use of antigen B and derivatives for the diagnosis of CE patients (articles published from 2006).
Antigen | Number of CE patients | Confirmatory test | Technique, antibody | Sensitivity (%) | Negative serology more frequent when | Reference |
---|---|---|---|---|---|---|
Purified | 21 | Surgery | Immunochromatography, IgG | 100 | Not specified | [42] |
Immunochromatography, IgG4 | 95 | |||||
23 | Surgery | ELISA, IgG | 100 | Not specified | [46] | |
5 | Imaging techniques and serology∗ | 80 | ||||
13 | Serology∗ | 0 | ||||
32 | Imaging techniques | ELISA, IgG | 93.8 | CE4 and CE5 cyst stages | [16] | |
40 | Surgery | ELISA, IgG | 87.5 | Not specified | [30] | |
ELISA, IgG4 | 80 | |||||
108 | Surgery | DIGFA, IgG | 89.8 | Cyst location other than liver; CE1, CE4, and CE5 cyst stages; small cysts | [43] | |
113 | Imaging techniques | DIGFA, IgG | 92.9 | Not specified | [44] | |
35 | Imaging techniques | ELISA, IgG | 54 | CE1, CE4, and CE5 cyst stages | [63] | |
56 | Surgery | ELISA, all (Protein G) | 96.91 | Not specified | [37] | |
82.12 | ||||||
| ||||||
Recombinant B1 | 31 | Surgery | ELISA, all (Protein G) | 71 | Parasite genotype other than G1 | [38] |
124 | Surgery$ | ELISA, IgG | 83 | Not specified | [19] | |
246 | Imaging techniques | ELISA, all (Protein G) | 77.6 | Not specified | [64] | |
113 | Imaging techniques | DIGFA, IgG | 77.9 | Not specified | [44] | |
56 | Surgery | ELISA, all (Protein G) | 94.6 | Not specified | [37] | |
123 | Imaging techniques | ELISA, IgG | 73.9 | CE4 and CE5 cyst stages, no pretreatment | [15] | |
| ||||||
Recombinant B2 | 543 | Surgery | ELISA, IgG | 77.8 | Single cyst, no pretreatment | [17] |
1864 | 79 | |||||
124 | Surgery$ | ELISA, IgG | 62.9 | Not specified | [19] | |
| ||||||
Recombinant 2B2 | 543 | Surgery | ELISA, IgG | 92.6 | Single cyst, no pretreatment | [17] |
1864 | 87.6 | |||||
| ||||||
Recombinant B3 | 124 | Surgery$ | ELISA, IgG | 29 | Not specified | [19] |
| ||||||
Recombinant B4 | 124 | Surgery$ | ELISA, IgG | 75.8 | Not specified | [19] |
36 | Surgery | ELISA, IgG | 91.7 | Not specified | [39] | |
| ||||||
Recombinant B5 | 124 | Surgery$ | ELISA, IgG | 41.3 | Not specified | [19] |
| ||||||
P176 peptide | 61 | Surgery | ELISA, IgG | 78.7 | Lung cysts, no complications, single cyst, and small cysts | [48] |
63 | Surgery | ELISA, IgG | 23.8 | Not specified | [50] | |
| ||||||
Long D8-9 peptide | 35 | Imaging techniques | ELISA IgG | 74.3 | Not specified | [41] |
∗Positive serology against HF in ELISA IgG, 1EgAgB purified from a Chinese sheep isolate, 2EgAgB purified from a Iranian sheep isolate, $patients selected by their positivity in ELISA IgG against HF, 3Spanish patients, and 4Peruvian patients.