Table 1.
Plasma lipid profiles of Tie2-Scarb1 transgenic females on normal C57Bl/6N, Scarb1-KO, or apoE-KO backgrounds. All animals were kept on normal chow diet.
| Genotype | TC | TG | PL | FC | CE | HDL-C |
|---|---|---|---|---|---|---|
| Normal C57Bl/6N background | ||||||
| Tie2-Scarb1, N = 35–39 | 85 ± 2 | 66 ± 2a | 174 ± 4 | 20 ± 1 | 65 ± 2 | 45 ± 3b |
| Sibling control, N = 13 | 86 ± 3 | 79 ± 3 | 178 ± 7 | 22 ± 1 | 63 ± 2 | 61 ± 3 |
|
| ||||||
| ApoE-KO background | ||||||
| Tie2-Scarb1, N = 28–33 | 463 ± 17 | 131 ± 21 | 260 ± 7 | 127 ± 4 | 346 ± 12 | N/A |
| Sibling control, N = 9–11 | 455 ± 24 | 160 ± 42 | 240 ± 9 | 124 ± 9 | 333 ± 21 | N/A |
|
| ||||||
| Scarb1-KO background | ||||||
| Tie2-Scarb1, N = 15–19 | 232 ± 8 | 101 ± 6 | 316 ± 8 | 108 ± 7 | 124 ± 10 | 132 ± 6 |
| Sibling control, N = 9–12 | 221 ± 7 | 105 ± 5 | 310 ± 14 | 104 ± 5 | 118 ± 9 | 103 ± 16 |
All values are expressed in units of mg/dL. a P < 0.005; b P < 0.0002. TC: total cholesterol; TG: triglycerides; PL: phospholipids; FC: free cholesterol; CE: cholesteryl ester.