Table 2.

Summary of reviewed publications with S53P4 bioactive glass as treatment for chronic osteomyelitis.

Reference	Clinical indication	Number of treated patients with S53P4 implants	Application form	Number of successful treatments	Complications related to S53P4 implant	Study design	Follow-up period [months]	Examinations during follow-up
Romanò et al. [29, 30]	Chronic osteomyelitis	27	Granules (size not reported)	25	2 recurrences of infection (with 1 fracture)	Retrospective single centre cohort study	21.8 (average, range: 12–36)	Clinical and laboratory evaluation and radiographs
Lindfors et al. [31]	Chronic osteomyelitis	11	Granules (0.5–0.8, 0.8–1.0, 1.0–2.0, and 2.0–3.15 mm)	10	1 recurrence due to improper filling of the cavity	Retrospective multicentre cohort study	24 (average, range: 10–38)	Clinical examinations and radiological evaluation
McAndrew et al. [32]	Chronic osteomyelitis	3	Granules (size not reported)	3	None	Retrospective single centre case study	17.3 (average, range: 14–21)	Radiological, haematological, and biochemical examinations