Table 4.

Summary of reviewed publications with S53P4 bioactive glass as bone graft material in benign bone tumour treatment.

Reference	Clinical indication	Number of treated patients with S53P4 implants	Application form	Number of successful treatments	Complications related to S53P4 implant	Study design	Follow-up period [months]	Examinations during follow-up
Lindfors et al. [36]	Grafting of benign bone tumours	14	Granules (1.0–2.0 and 3.15–4.0 mm)	11	1 reoperation due to a residual cyst 2 fractures due to not following immobilization advice	Prospective single centre randomized study	36	CT and X-ray evaluation and blood sample examinations
Lindfors [37]	Recurrent aneurysmal bone cyst	1	Granules (0.5–0.8 mm)	1	None	A single case study	24	X-ray examination and clinical evaluation on function and growing
Lindfors et al. [38]	Grafting of benign bone tumours	11	Granules (1.0–2.0 and 3.15–4.0 mm)	11	None	Prospective single centre randomized study	168 (average, range: not reported)	Clinical examination, X-ray, MRI, and CT evaluation