Figure 3.
Similar patterns of disease were seen in C57BL/6 (B6) mice carrying the gld and lpr mutations following UV-B reactivation. Eyes of B6 wild-type (n = 20), B6-lpr (n = 15), and B6-gld (n = 15) mice were infected with 106 pfu of HSV-1, McKrae strain. Six weeks following infection mice were irradiated with UV-B to reactivate the latent infection. Corneal opacity was measured and compared between these strains of mice. ∗Significant virus-induced corneal opacity was observed for B6-gld (P < 0.01–0.001) at days 14–42 when compared to B6 controls. B6-lpr mice displayed significantly more opacity than did B6 controls at days 21 and 28 (P < 0.05–0.01).