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UC-MSCs immunosuppressed IL-22 by soluble cellular factors but not PGE2. (a) UC-MSCs inhibited CD4+T cells secreting IL-22 and the expression of IL-22 mRNA; (b) the immunoregulation of UC-MSCs on IL-22 was mediated by soluble cellular factors; (c) PGE2 did not involve in the immunoregulation of UC-MSCs on IL-22. Data represent one of the three independent experiments, each performed in triplicate. ∗∗∗ P < 0.001 and # P > 0.05.
