Table 2.
Autoimmune conditions in 35 hemochromatosis probands1.
| Condition | Percentage (n) |
|---|---|
| Hashimoto's thyroiditis2 | 54.3 (19) |
| Rheumatoid arthritis3 | 11.4 (4) |
| Ankylosing spondylitis4 | 5.7 (2) |
| Mixed connective tissue disorder | 5.7 (2) |
| Myasthenia gravis | 5.7 (2) |
| Pernicious anemia | 5.7 (2) |
| Sarcoidosis | 5.7 (2) |
| Ulcerative colitis | 5.7 (2) |
| Autoimmune hemolytic anemia5 | 2.9 (1) |
| Crohn's disease | 2.9 (1) |
| Elevated antinuclear antibody6 | 2.9 (1) |
| Graves' disease | 2.9 (1) |
| Polymyalgia rheumatica | 2.9 (1) |
| Primary biliary cirrhosis | 2.9 (1) |
| Psoriasis | 2.9 (1) |
| Raynaud's phenomenon | 2.9 (1) |
| Scleroderma | 2.9 (1) |
| Sjögren's syndrome | 2.9 (1) |
| Systemic lupus erythematosus | 2.9 (1) |
1Six probands had two or more autoimmune conditions. Two men had both Hashimoto's thyroiditis and pernicious anemia. One woman had both Hashimoto's thyroiditis and Crohn's disease. One woman had Hashimoto's thyroiditis, polymyalgia rheumatica, and systemic lupus erythematosus. One woman had Hashimoto's thyroiditis, Raynaud's phenomenon, sarcoidosis, scleroderma, and Sjögren's syndrome. One woman had both ulcerative colitis and biliary cirrhosis.
2Of 235 probands, 14 women and 5 men had Hashimoto's thyroiditis (8.1% [5.1, 12.5]).
3Of 235 probands, 2 men and 2 women had rheumatoid arthritis (1.7% [0.6, 4.6]).
4Of 235 probands, 2 men had ankylosing spondylitis (0.0085 [0.0015, 0.0337]).
5Mediated by IgG and complement.
6This proband had anti-nuclear antibody >1 : 320 without other manifestation of autoimmunity. Elevated anti-nuclear antibodies (>1 : 80) in other probands were interpreted as part of broader autoimmune condition diagnoses named separately.