Table 2.
Summary of multivariable regressions analyses predicting pretreatment neurocognitive functioning in breast cancer patients*
| Executive functioning (n = 151) | Processing speed (n = 136) | Verbal memory (n = 151) | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Predictor | β | R 2 | ∆R 2 | P † | CI | β | R 2 | ∆R 2 | P † | CI | β | R 2 | ∆R 2 | P † | CI |
| Block 1: | - | .282 | .282 | <.001 | (0.17 to 0.40) | - | .235 | .235 | <.001 | (0.12 to 0.35) | - | .220 | .220 | <.001 | (0.11 to 0.33) |
| Age, y | .10 | - | - | .39 | (-0.08 to 0.28) | -0.04 | - | - | .67 | (-0.24 to 0.16) | 0.26 | - | - | .006 | (0.08 to 0.50) |
| Years of education | 0.24 | - | - | <.001 | (0.08 to 0.40) | 0.37 | - | - | <.001 | (0.19 to 0.54) | 0.20 | - | - | .01 | (0.04 to 0.36) |
| Race | -0.30 | - | - | <.001 | (-0.44 to -0.16) | -0.20 | - | - | .01 | (-0.36 to -0.04) | -0.31 | - | - | <.001 | (-0.47 to -0.15) |
| Mood | 0.14 | - | - | .09 | (-0.02 to 0.30) | 0.11 | - | - | .19 | (-0.07 to 0.29) | -0.02 | - | - | .85 | (-0.19 to 0.16) |
| Fatigue | -0.12 | - | - | .16 | (-0.28 to 0.04) | -0.11 | - | - | .19 | (-0.29 to 0.07) | -0.05 | - | - | .60 | (-0.23 to 0.13) |
| BMI | -0.06 | - | - | .53 | (-0.26 to 0.14) | 0.05 | - | - | .73 | (-0.19 to 0.29) | 0.09 | - | - | .36 | (-0.11 to 0.29) |
| Block 2: | - | .306 | .024 | .03 | (0.01 to 0.07) | .263 | .028 | .04 | (0.01 to 0.07) | - | .234 | .013 | .12 | (-0.02 to 0.04) | |
| Comorbidity | -0.17 | - | - | .04 | (-0.33 to -0.01) | -0.18 | - | - | .04 | (--0.36 to -0.00) | -0.13 | - | - | .11 | (-0.29 to 0.03) |
| Block 3: | - | .317 | .011 | .29 | (-0.02 to 0.04) | - | .268 | .005 | .83 | (-0.01 to 0.02) | - | .294 | .060 | .01 | (0.00 to 0.12) |
| Log IL-6 | -0.08 | - | - | .33 | (-0.26 to 0.10) | 0.00 | - | - | .91 | (-0.22 to 0.22) | -0.02 | - | - | .85 | (-0.22 to 0.18) |
| Log sTNFR-II | -0.07 | - | - | .29 | (-0.27 to 0.13) | 0.02 | - | - | .87 | (-0.18 to 0.22) | -0.31 | - | - | .002 | (-0.51 to -0.11) |
| Log IL-1ra | 0.13 | - | - | .07 | (-0.07 to 0.33) | 0.08 | - | - | .76 | (-0.14 to 0.30) | 0.23 | - | - | .02 | (0.03 to 0.43) |
*Sample size varies because of missing data as assessments were occasionally shortened to accommodate patients’ clinic appointment schedule. Results for block 2 are adjusted for block 1, and results for block 3 are adjusted for all other blocks in the model; - indicates cells which are not plausible. β = standardized regression coefficients; CI = confidence interval; R2 = R square; ∆R2= R square change.
† P = relevant probability value associated with the appropriate test (F statistics for ∆R2 and t statistics for beta weights, all tests two-sided).