Table 3.
Summary of cognitive, adaptive, and behavioral test scores by sex in subjects administered module 2 of the Autism Diagnostic Observation Schedule (ADOS) in 3 research datasets.
| Autism Genetics Resource Exchange (AGRE) | Autism Treatment Network (ATN) | Simons Simplex Collection (SSC) | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| M | F | d (95% CI) | p | M | F | d (95% CI) | p | M | F | d (95% CI) | p | |
| Total Subjects | 268 | 58 | 326 | 52 | 351 | 69 | ||||||
| Age in years, Mean (SD) | 8.1 (2.9) | 8.1 (2.5) | 0.00 (−0.25–0.25) | .90 | 7.0 (2.4) | 7.7 (2.4) | 0.29 (0.00–0.58) | .045 | 8.3 (3.1) | 8.9 (3.1) | 0.19 (−0.06–0.45) | .14 |
| Full Scale IQ | ||||||||||||
| Subjects with data, %(N)a | 33% (88) | 30% (17) | 69% (225) | 75% (39) | 100% (351) | 99% (68) | ||||||
| Mean (SD) | 68 (18) | 66 (16) | 0.10 (−0.35–0.55) | .69 | 74 (23) | 61 (15) | 0.57 (0.33–0.82) | <.001 | 69 (19) | 62 (19) | 0.41 (0.15–0.68) | .002 |
| Vineland Adaptive Behavior Scales Standard Scores | ||||||||||||
| Subjects with data, %(N)a | 84% (225) | 76% (44) | 91%b (296) | 94% (49) | 100% (351) | 100% (69) | ||||||
| Communication, Mean (SD) | 67 (19) | 65 (23) | 0.11 (−0.27–0.48) | .54 | 76 (12) | 70 (12) | 0.50 (0.20–0.79) | .001c | 74 (11) | 71 (11) | 0.33 (0.07–0.59) | .01 |
| Daily living skills, Mean (SD) | 58 (21) | 58 (23) | 0.01 (−0.33–0.36) | .94 | 76 (12) | 71 (12) | 0.40 (0.11–0.68) | .009c | 73 (12) | 71 (11) | 0.23 (−0.01–0.48) | .07 |
| Socialization, Mean (SD) | 61 (14) | 61 (17) | 0.03 (−0.36–0.43) | .84 | 72 (12) | 68 (11) | 0.33 (0.05–0.64) | .013 | 69 (11) | 66 (12) | 0.26 (0.00–0.53) | .05 |
| Adaptive Behavior Composite, Mean (SD) | 59 (17) | 59 (20) | 0.05 (−0.33–0.42) | .78 | 72 (11) | 68 (10) | 0.36 (0.08–0.64) | .014 | 71 (10) | 68 (10) | 0.29 (0.03–0.56) | .03 |
| Social Responsiveness Scale Raw Scores | ||||||||||||
| Subjects with data, %(N)a | 65% (174) | 57% (33) | 0% (0) | 0% (0) | 100% (350) | 100% (69) | ||||||
| Total Score, Mean (SD) | 104 (30) | 109 (25) | 0.17 (−0.16–0.49) | .36 | - | - | 99 (26) | 106 (25) | 0.28 (0.03–0.54) | .03 | ||
| Child Behavior Checklist (age 6–18 years) T-scores | ||||||||||||
| Subjects with data, %(N)a | 0% (0) | 0% (0) | 48% (159) | 63% (33) | 69% (248) | 78% (54) | ||||||
| Internalizing, Mean (SD) | - | - | 60 (10) | 59 (10) | 0.12 (−0.27–0.50) | .55 | 57 (9) | 57 (9) | 0.02 (−0.27–0.31) | .89 | ||
| Externalizing, Mean (SD) | - | - | 58 (9) | 60 (10) | 0.24 (−0.17–0.65) | .26 | 56 (9) | 59 (8) | 0.41 (0.14–0.67) | .01 | ||
| Total Problems, Mean (SD) | - | - | 64 (8) | 65 (8) | 0.16 (−0.05–0.53) | .37 | 61 (8) | 64 (7) | 0.33 (0.08–0.57) | .03 | ||
On Social Responsiveness Scale and Child Behavior Checklist higher scores represent more impairment. The Autism Consortium dataset was not analyzed for modules 1 or 2.
a
Percentage of subjects of that sex with available data for each measure.
b
N varies: n=297 for Vineland communication and daily living skills scores for males in ATN.
c
Survived false discovery rate correction.