Table 4.
Summary of cognitive, adaptive, and behavioral test scores by sex in subjects administered module 3 of the Autism Diagnostic Observation Schedule (ADOS) in 4 research datasets.
| Autism Genetics Resource Exchange (AGRE) |
Autism Consortium (AC) |
Autism Treatment Network (ATN) |
Simons Simplex Collection (SSC) |
|||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| M | F | d (95 % CI ) |
p | M | F | d | p | M | F | d | p | M | F | d | p | |
| Total Subjects | 571 | 131 | 129 | 22 | 808 | 127 | 1293 | 169 | ||||||||
| Age in years, Mean (SD) | 9.9 (3.1) | 9.4 (2.7) | 0.13 (−0.40 – 0.65 ) | . 17 | 9.8 (3.2) | 9.6 (3.3) | 0.07 (−0.40 – 0.53 ) | .77 | 9.2 (2.7) | 9.3 (2.8 ) | 0.04 (−0.16–0.23) | .70 | 9.9 (3.0) | 10.2 (3.4) | 0.10 (−0.08–0.28) | .27 |
| Full Scale IQ | ||||||||||||||||
| Subjects with data, %(N)a | 41% (233) | 38% (50) | 94% (121) | 100% (22) | 73% (592) | 64% (81) | 100% (1292) | 100% (169) | ||||||||
| Mean (SD) | 93 (20) | 92 (20) | 0.01 (−0.13 – 0.15 ) | . 85 | 98 (18) | 93 (21) | 0.29 (−0.22 – 0.81 ) | .22 | 92 (20) | 92 (20) | 0.02 (−0.22–0.26) | .87 | 95 (19) | 91 (21) | 0.20 (0.03–0.37) | .02 |
| Vineland Adaptive Behavior Scales Standard Scores | ||||||||||||||||
| Subjects with data, %(N)a | 74% (422) | 78% (102) | 94%b (121) | 100% (22) | 88%b (711) | 87 %b (111 ) | 100% (1293) | 100% (169) | ||||||||
| Communication, Mean(SD) | 78 (17) | 81 (14) | 0.17 (−0.02 – 0.36 ) | . 11 | 83 (13) | 89 (18) | 0.43 (−0.16–1.01) | .08 | 80 (12) | 82 (14) | 0.17 (−0.05–0.39) | .12 | 82 (12) | 81 (12) | 0.10 (−0.06–0.27) | .21 |
| DLS, Mean (SD) | 67 (20) | 71 (19) | 0.16 (−0.07 – 0.39 ) | . 16 | 83 (17) | 83 (13) | 0.00 (−0.37–0.37) | 1. 0 | 80 (13) | 82 (14) | 0.13 (−0.09–0.35) | .24 | 81 (12) | 79 (12) | 0.17 (0.01–0.33) | .04 |
| Socialization, Mean (SD) | 67 (15) | 70 (14) | 0.21 (0.00–0.42 ) | . 05 | 75 (12) | 84 (16) | 0.69 (0. 12–1.25) | .005c | 72 (11) | 74 (10) | 0.15 (−0.03–0.33) | .11 | 75 (11) | 75 (10) | 0.00 | .93 |
| Composite, Mean (SD) | 68 (16) | 71 (14) | 0.16 (−0.03 – 0.36 ) | . 14 | 79 (14) | 83 (13) | 0.29 (−0.16–0.74) | .21 | 76 (10) | 78 (11) | 0.20 (−0.02–0.41) | .07 | 77 (10) | 76 (10) | 0.11 | .16 |
| Social Responsiveness Scale Raw Scores | ||||||||||||||||
| Subjects with data, %(N)a | 61% (346) | 63% (83) | 78% (101) | 86% (19) | 0% (0) | 0% (0) | 99% (1291) | 100% (169) | ||||||||
| Total Score, Mean (SD) | 97 (31) | 89 (31) | 0.25 (0. 01–0.49) | .039 | 96 (26) | 78 (27) | 0. 68 | .007c | - | - | 95 (27) | 94 (27) | 0.02 (−0.14–0.18) | .80 | ||
| Child Behavior Checklist ( age 6–18 years) T-scores | ||||||||||||||||
| Subjects with data, %(N)a | 0% (0) | 0% (0) | 60% (77) | 68% (15) | 82% (663) | 80% (102) | 80% (1187) | 92% (156) | ||||||||
| Internalizing, Mean (SD) | - | - | 62 (11) | 56 (10) | 0.58 (0. 05–1.11 ) | .042 | 64 (10) | 65 (9.0 ) | 0.13 (−0.06–0.33) | .18 | 61 (10) | 61 (10) | 0.01 (−0.17–0.19) | .90 | ||
| Externalizing, Mean (SD) | - | - | 57 (11) | 54 (11) | 0.20 (−0.35–0.76) | .47 | 59 (11) | 61 (11) | 0.21 (0.00–0.42) | .044 | 57 (12) | 57 (11) | 0.07 (−0.09–0.23) | .39 | ||
| Total Problems, Mean (SD) | - | - | 64 (9) | 58 (11) | 0.65 (0. 01–1.29 ) | .028 | 66 (8) | 68 (7) | 0.21 (0.04–0.39) | .023 | 63 (9) | 64 (9) | 0.09 (−0.07–0.25) | .26 | ||
DLS- Daily Living Skills; on Social Responsiveness Scale and Child Behavior Checklist higher scores represent more impairment.
a
Percentage of subjects of that sex with available data for each measure.
b
N varies: n=119 for Vineland Composite scores for males in AC; n=719 for males and n=113 for females for Communication and Socialization scores in ATN; n=718 for males and n=114 for females for DLS scores in ATN.
c
Survived false discovery rate correction.