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. Author manuscript; available in PMC: 2016 Nov 1.
Published in final edited form as: Neurobiol Aging. 2015 Aug 15;36(11):2946–2953. doi: 10.1016/j.neurobiolaging.2015.08.008

Figure 3.

Figure 3

summarizes the path analysis of APOE genotypes and CAA where the model links the presence of APOE ε2 allele, and separately ε4 allele, with CAA, either directly or indirectly through an effect on AD pathology. The path coefficients (standard errors) estimate the associations of APOE genotypes with AD and subsequently CAA. All the coefficients are significant, and the result reveals that there is a significant direct effect of ε2 on CAA which is masked by the allele’s negative association with AD pathology.