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. Author manuscript; available in PMC: 2016 Nov 1.
Published in final edited form as: Neurobiol Aging. 2015 Aug 15;36(11):2946–2953. doi: 10.1016/j.neurobiolaging.2015.08.008

Table 2.

Association of APOE with meningeal/parenchymal CAA

Model 1
OR (95% CI)		 Model 2
OR (95% CI)		 Model 3
OR (95% CI)
Age at death 1.050 (1.032, 1.069)* 1.033 (1.015, 1.052)* 1.033 (1.014, 1.052)*
Male Sex 1.038 (0.817, 1.320) 1.175 (0.921, 1.500) 1.184 (0.927, 1.511)
Education 0.998 (0.967, 1.029) 1.003 (0.971, 1.035) 1.003 (0.972, 1.036)
AD1 - 5.537 (3.970, 7.721)* 5.597 (4.009, 7.814)*
Macroscopic infarcts - - 0.926 (0.724, 1.184)
Microinfarcts - - 1.210 (0.937, 1.563)
Lewy Bodies - - 0.954 (0.725, 1.257)
APOE ε2 1.212 (0.887, 1.658) 1.707 (1.236, 2.358)* 1.709 (1.237, 2.361)*
APOE ε4 3.554 (2.728, 4.630)* 2.284 (1.730, 3.014)* 2.296 (1.739, 3.032)*
1

Composite measure of AD pathology;

*

p<0.05;

Model 1 was adjusted for demographics; Model 2 was adjusted for demographics and AD pathology; Model 3 was adjusted for demographics, AD pathology, as well as presence of infarcts and Lewy bodies.