Table 1.
Indvidual renal cortical mRNA and protein levels induced by the test agents administered alone or in combination at 4 hrs (Table 1a) and 18 hrs (Table 1b) post injection.
| a. Kidney mRNA and protein values 4 hrs post Rx | ||||
|---|---|---|---|---|
| Kidney mRNA | Control | N-Mgb | SnPP | SnPP+N-Mgb |
| HO-1 | 0.61±0 1 | 3.38±0.38 | 4.38±0.28 | 10.5±1.23 <0.0001 |
| Haptoglobin | 0.20±0.06 | 1.94±0.31 | 0.19±0.01 | 5.45±1.16 <0.005 |
| IL-10 | 0.56±0.20 | 1.45±0.6 | 0.39±0.15 | 5.18±1.23 <0.005 |
| Kidney Protein | Control | N-Mgb | SnPP | SnPP+N-Mgb |
| HO-1 protein | 13.3.±1.3 | 36.1±2.9 | 22.9±2.6 | 55.5±3.7 <0.001 |
| Haptoglobin | 7.9±1.9 | 17.6±1 | 13.1±1.3 | 18.9±2.7 <0.001 |
| IL-10 | 304±29 | 265±54 | 550±86 | 838±63 <0.001 |
| b. Kidney mRNA and protein values 18 hrs post Rx | ||||
|---|---|---|---|---|
| Kidney mRNA cortex |
Control | N-Mgb | SnPP | SnPP+N-Mgb |
| HO-1 | 0.61±0 1 | 0.58±0.18 | 0.63±0.06 | 1.45±0.61 (NS) |
| Haptoglobin | 0.20±0.06 | 0.24± 0.04 | 0.23±0.08 | 0.4±0.19 (NS) |
| IL-10 | 0.56±0.20 | 0.43±0.10 | 0.18±0.09 | 0.57±0.13 (NS) |
| Kidney Protein | Control | N-Mgb | SnPP | SnPP+N-Mgb |
| HO-1 | 13.3±1.3 | 30±6 | 18±2 | 71±10 <0.001 |
| Haptoglobin | 10.3±2.7 | 183.8±20.4 | 53.5±17.2 | 203±8 <0.0001 |
| IL-10 | 304±29 | 292±54 | 454±51 | 840±60 <0.001 |