Table 2.
Indvidual liver mRNA and protein levels induced by the test agents administered alone or in combination at 4 hrs (Table 1a) and 18 hrs (Table 1b) post injection.
| a: Liver mRNA and protein levels 4 hrs post Rx | ||||
|---|---|---|---|---|
| Liver mRNA 4 hrs post Rx |
control | N-Mgb | SnPP | SnPP+N-Mgb |
| HO-1 | 1.1±0.12 | 1.83±0.33 | 3.15±.25 | 5.66±0.29 <0.001 |
| Haptoglobin | 0.5±0.1 | 0.98±0.1 | 0.32±0.02 | 1.01±0.12 <0.01 |
| IL-10 | 0.06±0.0.02 | 0.67±0.46 | 0.14±0.1 | 1.12±0.64 <0.001 |
|
Liver protein 4 hrs post Rx |
control | N-Mgb | SnPP | SnPP+N-Mgb |
| HO-1 protein | 10.2±1.2 | 17±2 | 7.4±0.7 | 15.1±1.4 <0.025 |
| Haptoglobin | 115.3±9.6 | 359.5±39.6 | 130.0±8.9 | 351.0±40.7 <0.001 |
| IL-10 | 314±36 | 286±32 | 485±47 | 412±34 =0.1 |
| b: Liver mRNA and protein levels 18 hrs post Rx | ||||
|---|---|---|---|---|
|
Liver mRNA 18 hrs post Rx |
control | N-Mgb | SnPP | SnPP+N-Mgb |
| HO-1 | 1.1 ±0.12 | 0.82±0.07 | 2.56±0.21 | 2.86±0.4 <0.001 |
| Haptoglobin | 0.5±0.1 | 0.91±0.07 | 0.65±0.17 | 1.19±0.4 <0.05 |
| IL-10 | 0.06±0.02 | 0.06±0.02 | 0.05±0.01 | 0.06±0.02 (NS) |
|
Liver protein 18 hrs post Rx |
control | N-Mgb | SnPP | SnPP+N-Mgb |
| HO-1 protein | 10.2±1.2 | 14.9±0.3 | 18±2.5 | 22.9±1.2 <0.0001 |
| Haptoglobin | 115.3±9.6 | 358.8±32.8 | 212.0±63.6 | 410±64.3 <0.001 |
| IL-10 | 314±36 | 5988±549 | 8198±725 | 8015±225 <0.001 |