Table 3.

Indvidual cardiac mRNA and protein levels induced by the test agents administered alone or in combination at 4 hrs (Table 1a) and 18 hrs (Table 1b) post injection.

a: Cardiac mRNA and protein levels 4 hrs post Rx
Cardiac mRNA 4 hrs post Rx	Control	N-Mgb	SnPP	SnPP+N-Mgb
HO-1	0.07±0.01	0.09±0.01	0.14±0.01	0.3±0.01 <0.001
Haptoglobin	0.31±.0.07	0.75±0.10	0.52±0.21	1.32±0.22 <0.002
IL-10	0.36±0.10	0.86±0.11	0.58±0.16	0.96±0.22 <0.04
Cardiac protein 4 hrs post Rx	control	N-Mgb	SnPP	SnPP+N-Mgb
HO-1	1.50±08	1.64±0.19	1.310.13	1.54±0.09 (NS)
Haptoglobin	15.6±5.0	40.4±8.6	19.1±2.1	29.4±4.1 <0.1
IL-10	8.1 ±5	21±12	15.8±10	41±14 <0.035

b: Cardiac mRNA and protein levels 18 hrs post Rx
Cardiac mRNA 18 hrs post Rx	control	N-Mgb	SnPP	SnPP+N-Mgb
HO-1	0.07±0.01	0.08±0.01	0.09±0.03	0.24±0.07 <0.005
Haptoglobin	0.31±.0.07	0.53±0.21	0.59±0.17	1.28±0.2 <0.002
IL-10	0.36±0.10	0.67±0.10	0.53±0.10	0.64±0.14 =0.1
Cardiac protein 18 hrs post Rx	control	N-Mgb	SnPP	SnPP+N-Mgb
HO-1	1.5±0.08	1.9.7±0.37	2.67±0.4	4.2±.98 <0.01
Haptoglobin	15.6±5.0	249.6±15.0	96.1±36.2	250.7±37.8 <0.001
IL-10	8±5	14.5±10	23.4±14	51.4±19 <0.035