Table 4.
Study | Histological Subtypes |
BRAF mutations |
NRAS mutations |
HRAS alterations |
---|---|---|---|---|
(Bastian et al., 1999) | Spitz Nevi | -- | -- | 4/17(23.5%)* |
(Bastian et al., 2000) | Spitz Nevi | -- | -- | 12/102(12%)* |
(Yazdi et al., 2003) | Spitz Nevi | 0/69(0%) | -- | -- |
(Palmedo et al., 2004) | Spitz Nevi | 0/21(0%) | -- | -- |
(Mihic-Probst et al., 2004) | Spitz Nevi | 0/20(0%) | -- | -- |
(Saldanha et al., 2004) | Spitz Nevi | 0/26(0%) | 1/16(6.25%) | -- |
(Gill et al., 2004) | Spitz Nevi | 0/30(0%) | 0/30(0%) | 0/30(0%) |
(Turner et al., 2005) | Spitz Nevi | 0/24(0%) | -- | -- |
(van Dijk et al., 2005) | Spitz Nevi and Atypical Spitz Nevi | 0/30(0%) | 0/30(0%) | 6/30(20%) |
(Fullen et al., 2006) | Spitz Nevi | 10/48(20.8%) | 1/48(2.08%) | -- |
(La Porta et al., 2006) | Spitz Nevi | 8/8(100%) | -- | -- |
(Takata et al., 2007) | Spitz Nevi | 0/12(0%) | 0/12(0%) | 0/12(0%) |
(Da Forno et al., 2009) | Spitz Nevi and Atypical Spitz Nevi | 2/22(9.1%) | 2/22(9.1%) | 2/19(10.5%) |
(Emley et al., 2010) | Spitz Nevi and Atypical Spitz Nevi | 1/20(5%) | 0/20(0%) | -- |
(van Engen-van Grunsven et al., 2010) | Spitz Nevi | -- | -- | 24/93(25.8%) |
These studies reported frequency of copy number gain, not mutation