Table 4.
Studies evaluating the genetic alteration status of BRAF, NRAS, and HRAS in Spitz nevi.
| Study | Histological Subtypes |
BRAF mutations |
NRAS mutations |
HRAS alterations |
|---|---|---|---|---|
| (Bastian et al., 1999) | Spitz Nevi | -- | -- | 4/17(23.5%)* |
| (Bastian et al., 2000) | Spitz Nevi | -- | -- | 12/102(12%)* |
| (Yazdi et al., 2003) | Spitz Nevi | 0/69(0%) | -- | -- |
| (Palmedo et al., 2004) | Spitz Nevi | 0/21(0%) | -- | -- |
| (Mihic-Probst et al., 2004) | Spitz Nevi | 0/20(0%) | -- | -- |
| (Saldanha et al., 2004) | Spitz Nevi | 0/26(0%) | 1/16(6.25%) | -- |
| (Gill et al., 2004) | Spitz Nevi | 0/30(0%) | 0/30(0%) | 0/30(0%) |
| (Turner et al., 2005) | Spitz Nevi | 0/24(0%) | -- | -- |
| (van Dijk et al., 2005) | Spitz Nevi and Atypical Spitz Nevi | 0/30(0%) | 0/30(0%) | 6/30(20%) |
| (Fullen et al., 2006) | Spitz Nevi | 10/48(20.8%) | 1/48(2.08%) | -- |
| (La Porta et al., 2006) | Spitz Nevi | 8/8(100%) | -- | -- |
| (Takata et al., 2007) | Spitz Nevi | 0/12(0%) | 0/12(0%) | 0/12(0%) |
| (Da Forno et al., 2009) | Spitz Nevi and Atypical Spitz Nevi | 2/22(9.1%) | 2/22(9.1%) | 2/19(10.5%) |
| (Emley et al., 2010) | Spitz Nevi and Atypical Spitz Nevi | 1/20(5%) | 0/20(0%) | -- |
| (van Engen-van Grunsven et al., 2010) | Spitz Nevi | -- | -- | 24/93(25.8%) |
*
These studies reported frequency of copy number gain, not mutation