Table 1.
Baseline characteristics according to AHSG genotypes in CHS
| SNP | rs4917 | rs2248690 | ||||||
|---|---|---|---|---|---|---|---|---|
| Alleles | CC | Ct | tt |
P for trend |
AA | At | tt |
P for trend |
| N participants (%) | 1583 (48) | 1372 (42) | 344 (10) | 1855 (56) | 1236(37) | 208 (6) | ||
| Fetuin-A levels, g/L (SD) | 0.51 (0.002) | 0.45 (0.002) | 0.39 (0.005) | <0.0001 | 0.50 (0.002) | 0.44 (0.002) | 0.38 (0.006) | <0.0001 |
| Mean age, years (SD) | 74.5 (5.2) | 74.7 (5.2) | 75.2 (5.6) | 0.02 | 75 (5) | 75 (5) | 75 (5) | 0.51 |
| Male, N (%) | 617 (40) | 534 (40) | 138 (40) | 0.78 | 718 (39) | 484 (39) | 87 (41) | 0.47 |
| African American, N (%) | 318 (20) | 212 (15) | 36 (10) | <0.001 | 304 (16) | 227 (18) | 35 (17) | 0.31 |
| Less than high school education, N (%) | 413 (26) | 341 (25) | 93 (27) | 0.06 | 472 (25) | 311 (25) | 64 (30) | 0.34 |
| Mean BMI, kg/m2 (SD) | 27 (5) | 27 (5) | 27 (5) | 0.58 | 27 (5) | 27 (5) | 27 (5) | 0.42 |
| Mean physical activity, kcal/day (IQR) | 893 (1705) | 855 (1695) | 750 (1395) | 0.06 | 903 (1730) | 825 (1680) | 696 (1300) | 0.07 |
| Current smoker, N (%) | 180 (12) | 128 (9) | 32 (9) | 0.24 | 194 (11) | 127 (10) | 19 (9) | 0.98 |
| No alcohol intake, N (%) | 872 (55) | 714 (52) | 192 (56) | 0.56 | 55 (1011) | 52 (649) | 57 (118) | 0.81 |
| Prevalent type 2 diabetes, N (%) | 240 (15) | 220 (16) | 49 (14) | 0.99 | 277 (15) | 199 (16) | 33 (16) | 0.43 |
| Prevalent hypertension, N (%) | 1020 (64) | 860 (62) | 225 (65) | 0.81 | 1190 (64) | 776 (63) | 139 (66) | 1.00 |
| Systolic blood pressure, mmHg (SD) | 137 (22) | 136 (21) | 136 (21) | 0.39 | 137 (22) | 136 (21) | 137 (21) | 0.98 |
| Diastolic blood pressure, mmHg (SD) | 72 (11) | 72 (11) | 72 (11) | 0.60 | 71 (11) | 72 (11) | 73 (11) | 0.15 |
| Mean eGFR, ml/min/1.73m2 (SD) | 74 (18) | 74 (18) | 74 (18) | 0.75 | 73 (18) | 75 (19) | 74 (19) | 0.02 |
| Median C-reactive protein, g/L (IQR) | 2.5 (4.4) | 2.6 (4.8) | 2.6 (4.9) | 0.34 | 2.5 (4.4) | 2.6 (4.6) | 3.2 (5.4) | 0.14 |
| Mean LDL cholesterol, mg/dL (SD) | 128 (34) | 127 (35) | 123 (31) | 0.02 | 128 (34) | 126 (33) | 125 (32) | 0.12 |
| Mean HDL cholesterol, mg/dL (SD) | 54 (15) | 54 (14) | 54 (15) | 0.55 | 54 (14) | 54 (15) | 54 (15) | 0.80 |
| Median triglycerides, mg/dL (IQR) | 121 (83) | 123 (83) | 121 (81) | 0.36 | 123 (82) | 123 (82) | 122 (87) | 0.85 |
| Use of oral hypoglycemic, N (%) | 94 (6) | 90 (7) | 20 (6) | 0.78 | 113 (6) | 75 (6) | 16 (8) | 0.57 |
| Estrogen use women, N (%) | 135 (9) | 126 (9) | 23 (7) | 0.61 | 175 (9) | 95 (8) | 14 (7) | 0.05 |
| Mean internal carotid IMT, mm (SD) | 1.41 (0.55) | 1.39 (0.54) | 1.40 (0.57) | 0.81 | 1.40 (0.54) | 1.41 (0.56) | 1.38 (0.54) | 0.74 |
| Mean common carotid IMT, mm (SD) | 1.08 (0.23) | 1.05 (0.21) | 1.08 (0.24) | 0.22 | 1.07 (0.23) | 1.06 (0.21) | 1.08 (0.26) | 0.45 |
| Mean ankle-arm index, (SD) | 1.08 (0.18) | 1.09 (0.16) | 1.09 (0.17) | 0.22 | 1.08 (0.17) | 1.09 (0.17) | 1.08 (0.17) | 0.78 |
| Coronary calcium score, (IQR) | 277 (809) | 332 (802) | 258 (481) | 0.49 | 321 (864) | 251 (731) | 367 (429) | 0.61 |