Table 3.

Differences in subclinical cardiovascular risk measures per 1SD difference in fetuin-A and per 1 SD difference in genetically predicted fetuin-A in CHS cohort.

CHS cohort		Caucasians		African Americans
			P		P
IMT1	Measured fetuin-A	n= 3,177		n= 658
	Adjusted for age, sex, clinic	0.025 (− 0.003– 0.054)	0.08	0.011 (− 0.054– 0.076)	0.74
	Genetically predicted fetuin-A	n= 3,177		n= 658
	rs2248690	− 0.017 (− 0.089– 0.055)	0.64	0.062 (− 0.215– 0.339)	0.66
	rs4917	− 0.004 (− 0.069– 0.061)	0.90	0.118 (− 0.093– 0.328)	0.27
	Both variants	− 0.008 (− 0.072– 0.055)	0.80	0.106 (− 0.095– 0.307)	0.30
AAI2	Measured fetuin-A	n= 2,568		n= 545
	Adjusted for age, sex, clinic	− 0.001 (− 0.007– 0.005)	0.71	0.004 (− 0.015– 0.023)	0.66
	Genetically predicted fetuin-A	n= 2,568		n= 545
	rs2248690	− 0.002 (− 0.017– 0.012)	0.74	− 0.053 (− 0.110– 0.003)	0.07
	rs4917	− 0.006 (− 0.002– 0.008)	0.44	− 0.053 (− 0.131– 0.025)	0.19
	Both variants	− 0.005 (− 0.018–0.009)	0.50	− 0.053 (− 0.108–0.002)	0.06
CAC3	Measured fetuin-A	n= 347		n= 113
	Adjusted for age, sex, clinic	29.3 (– 71.0– 129.6)	0.57	31.3 (− 87.1– 149.7)	0.60
	Genetically predicted fetuin-A	n= 347		n= 113
	rs2248690	99.3 (− 120.6– 319.3)	0.38	128.7 (− 239.2– 496.6)	0.49
	rs4917	155.1 (− 45.5– 355.7)	0.13	− 3.0 (− 424.1– 418.1)	0.99
	Both variants	136.8 (− 57.2– 330.8)	0.17	59.7 (− 311.2– 430.6)	0.75

¹Intima media thickness in mm

²Ankle-arm index

³Coronary artery calcium score.