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. Author manuscript; available in PMC: 2016 Oct 26.
Published in final edited form as: Vaccine. 2015 Sep 21;33(43):5845–5853. doi: 10.1016/j.vaccine.2015.08.086

Figure 5. Functional antibody titers are greater following SL vaccination with formulations containing CRX-601 or MGC.

Figure 5

Mice were vaccinated SL with the indicated dose of either flu antigen alone or flu antigen in combination with MGC, CRX-601 or MGC-CRX-601. IM positive control mice were vaccinated two times and are included for comparison. Serum collected on day 56 was analyzed by HAI assay for functional antibody titers. The horizontal dashed line represents the titer necessary for seroconversion (S.C.). Serum samples that did not demonstrate hemagglutination at the lowest dilution (1/20) are represented as a value of 1. The number of mice per group that seroconverted (samples were not diluted), out of the total mice per group, is shown on the X-axis. The mean and standard error are indicated. Data were analyzed by one-way ANOVA with Dunnett post-test. *, p <0.05, **, p <0.005, ***, p <0.0005, ****, p <0.0001 compared to the flu antigen only group.