Table 1. Variables and responses from the central composite design.

Variables					Responses
Run #	Type of Design Point	Total Amount of PLGA (mg)	DLG7E Ratio (%)	Dexamethasone (mg)	Drug Loading (%)	Burst Release (%)	Encapsulatin Efficiency (%)
CCD-1	Star	500.00	20.00	75.00	9.71	37.21	74.44
CCD-2	Edge	559.46	83.78	60.13	9.29	10.26	95.73
CCD-3	Star	500.00	60.00	100.00	13.36	13.71	80.16
CCD-4	Edge	559.46	83.78	89.87	13.18	10.33	95.23
CCD-5	Edge	559.46	36.22	89.87	11.19	30.13	80.85
CCD-6	Star	500.00	60.00	50.00	8.66	12.10	95.26
CCD-7	Center	500.00	60.00	75.00	12.12	18.92	92.92
CCD-8	Star	400.00	60.00	75.00	12.13	21.08	76.82
CCD-9	Center	500.00	60.00	75.00	11.47	17.93	87.94
CCD-10	Edge	440.54	83.78	60.13	11.25	9.75	93.67
CCD-11	Center	500.00	60.00	75.00	11.55	17.87	88.55
CCD-12	Center	500.00	60.00	75.00	11.21	15.17	85.94
CCD-13	Edge	440.54	36.22	89.87	14.32	35.20	84.52
CCD-14	Edge	559.46	36.22	60.13	8.77	15.20	90.37
CCD-15	Star	500.00	100.00	75.00	12.84	5.18	98.44
CCD-16	Center	500.00	60.00	75.00	11.32	14.28	86.79
CCD-17	Star	600.00	60.00	75.00	9.81	14.27	88.29
CCD-18	Edge	440.54	83.78	89.87	15.90	12.10	93.84
CCD-19	Edge	440.54	36.22	60.13	11.23	20.47	93.51
CCD-20	Center	500.00	60.00	75.00	12.41	15.38	95.14