TABLE 1.
Association of 1-log-unit increases in log10-transformed HPV31 DNA loads at the first positive visit with risk of concurrent diagnosis of CIN2–3
| Subjects and cervical cytological results at first positive visita | Women with <CIN2 |
Women with CIN2–3 |
Crude OR (95% CI) | Adjusted OR (95% CI)c | ||
|---|---|---|---|---|---|---|
| No. | Viral load (log10 copies/ng) (mean ± SD)b | No. | Viral load (log10 copies/ng) (mean ± SD) | |||
| All women | ||||||
| Overall | 442 | 3.17 ± 1.54 | 88 | 3.89 ± 1.27 | 1.4 (1.2–1.7) | 1.5 (1.2–1.9) |
| Within normal limits | 165 | 2.51 ± 1.40 | 8 | 3.33 ± 0.75 | 1.6 (0.9–2.9) | 1.5 (0.5–4.4) |
| ASCUS | 128 | 3.27 ± 1.48 | 25 | 3.63 ± 1.30 | 1.2 (0.9–1.7) | 1.3 (0.8–2.1) |
| LSIL | 125 | 3.89 ± 1.47 | 26 | 4.31 ± 1.43 | 1.2 (0.9–1.7) | 1.4 (1.0–2.1) |
| HSIL | 23 | 3.54 ± 1.36 | 28 | 3.91 ± 1.15 | 1.3 (0.8–2.0) | 1.5 (0.8–2.8) |
| Women without HPV16 coinfection at first positive visit | ||||||
| Overall | 360 | 3.20 ± 1.53 | 62 | 4.04 ± 1.18 | 1.5 (1.2–1.9) | 1.6 (1.2–2.1) |
| Within normal limits | 140 | 2.54 ± 1.35 | 7 | 3.32 ± 0.81 | 1.6 (0.9–3.1) | 1.8 (0.5–6.1) |
| ASCUS | 103 | 3.34 ± 1.49 | 16 | 3.99 ± 1.07 | 1.5 (0.9–2.3) | 1.6 (0.9–3.0) |
| LSIL | 100 | 3.93 ± 1.49 | 20 | 4.37 ± 1.20 | 1.3 (0.9–1.8) | 1.2 (0.8–1.9) |
| HSIL | 16 | 3.62 ± 1.22 | 18 | 4.01 ± 1.36 | 1.3 (0.7–2.2) | 2.1 (1.0–4.7) |
a
HPV, human papillomavirus; CIN, cervical intraepithelial neoplasia; ASCUS, atypical squamous cells of undetermined significance; LSIL, low-grade squamous intraepithelial lesion; HSIL, high-grade squamous intraepithelial lesion; SD, standard deviation; OR, odd ratio; CI, confidence interval.
b
Viral loads are presented as log10-transformed HPV31 copy number per nanogram of cellular DNA.
c
Adjusted for lineages of HPV31 variants (A, B, or C), coinfection with other oncogenic types (yes or no), and the timing of the initial HPV31 detection (at enrollment or during follow-up monitoring).