TABLE 1.

Agreement between MTS gradient concentration strips and CLSI broth microdilution reference method for caspofungin MIC determination for isolates with a dip effect

Species (n with dip effect/all isolates)	Median (range) MIC (mg/liter) by method:			MTS
				Top of the dip			New approach
				Median (range) MIC (mg/liter)	% agreement at no. of 2-fold dilutions:		Median (range) MIC (mg/liter)	% agreement at no. of 2-fold dilutions:
	Etest	Sensititre	CLSI		±1	±2		±1	±2
C. albicans (12/12)	0.125 (0.03–0.5)	0.06 (0.008–0.25)	0.125 (0.016–0.25)	0.25 (0.125–0.50)	58	83	0.125 (0.016–0.5)	75	92
C. glabrata (9/10)	0.25 (0.03–0.5)	0.125 (0.06–0.25)	0.125 (0.06–0.25)	0.50 (0.25–0.50)	22	89	0.125 (0.03–0.25)	100	100
C. parapsilosis (2/13)	0.4 (0.25–0.5)	0.19 (0.125–0.25)	0.125 (0.125–0.125)	0.50 (0.50–0.50)	0	100	0.09 (0.06–0.25)	100	100
C. tropicalis (11/11)	0.125 (0.06–0.5)	0.06 (0.016–0.25)	0.06 (0.016–0.25)	0.50 (0.125–0.50)	27	55	0.06 (0.03–0.25)	100	100
Rare Candida spp. (7/12)	0.25 (0.06–0.5)	0.125 (0.03–0.25)	0.125 (0.06–0.25)	0.50 (0.25–1.0)	43	57	0.06 (0.03–0.25)	86	100
All isolates (41/60)	0.125 (0.03–0.5)	0.06 (0.008–0.25)	0.125 (0.016–0.25)	0.50 (0.125–1.0)	37	73	0.125 (0.016–0.5)	88	100