TABLE 1.
Clinical characteristics of 13 patients with Yarrowia lipolytica fungemiaa
| Case | Isolate | Sex/Age (yr) | Reason for admission (comorbidities) | i.v. catheters (days)b | i.v. antibiotics | ICU | Specimen(s) | Treatment | Outcome |
|---|---|---|---|---|---|---|---|---|---|
| 1 | PW3298 | M/65 | Road traffic accident with traumatic subdural hematoma, multiple fractures, and gastrectomy | PVC (9) | Yes | No | Blood (peripheral) | Catheter removal and i.v. fluconazole 200 mg daily | Discharged after 14 days of hospitalization |
| 2 | PW3299 | M/46 | Postoperative fever (CRHD with valvular replacement) | PVC (11) | Yes | Yes | Blood (peripheral) | Catheter removal | Discharged after 20 days of hospitalization |
| 3 | PW3300 | M/27 | Fever with hypotension (cervical spinal fracture with paraplegia) | PICC (44) | Yes | Yes | Blood (PICC) | Catheter removal | Transferred to another hospital after 55 days of hospitalization |
| 4 | PW3301 | M/67 | Ischemic stroke with hemorrhagic transformation (ESRF) | CVC (7) | Yes | Yes | Blood (peripheral and CVC) | Catheter removal and i.v. itraconazole 350 mg daily | Discharged after 30 days of hospitalization |
| 5 | PW3302 | M/73 | Recurrent peritonitis (carcinoma of pancreas) | CVC (40) | Yes | Yes | Blood (peripheral and CVC) | Catheter removal and i.v. amphotericin B 25 mg | Discharged against medical advice after 45 days of hospitalization |
| 6 | PW3303 | M/1 | Apnea of prematurity | PVC (15) | Yes | No | Blood (peripheral) | Catheter removal | Discharged after 16 days of hospitalization |
| 7 | PW3304 | M/3 | Respiratory distress (congenital heart disease) | CVC (75) | Yes | Yes | Blood (peripheral and CVC) | Catheter removal and oral fluconazole 150 mg daily for 12 days | Discharged after 4 mo of hospitalization |
| 8 | PW3305 | M/63 | Bronchiectactic exacerbation (bronchiectasis) | PVC (6) | Yes | Yes | Blood (peripheral) | Catheter removal and i.v. fluconazole 400 mg daily for 5 days | Died after 10 days of hospitalization |
| 9 | PW3306 and PW3307 | M/75 | Intracerebral hemorrhage | CVC (30) | Yes | Yes | Blood (peripheral and CVC, respectively) | Catheter removal and i.v. fluconazole 400 mg daily for 14 days | Died after 35 days of hospitalization |
| 10 | PW3309 | M/43 | Pneumonia (brainstem death) | PVC (8) | Yes | No | Blood (peripheral) | Catheter removal | Discharged after 10 days of hospitalization |
| 11 | PW3310 | M/45 | Intestinal obstruction | CVC (38) | Yes | Yes | Blood (peripheral and CVC) | Catheter removal and i.v. fluconazole 400 mg daily for 27 days | Discharged after 49 days of hospitalization |
| 12 | PW3311 | M/73 | Open skull fracture | PVC (31) | Yes | Yes | Blood (peripheral) | Catheter removal and i.v. fluconazole 200 mg daily for 37 days | Discharged after 2 mo of hospitalization |
| 13 | PW3312 | F/82 | Right hip fracture | CVC (38) | Yes | Yes | Blood (peripheral and CVC) | Catheter removal and i.v. fluconazole 400 mg daily for 40 days | Died after 45 days of hospitalization |
a
The clinical data of 1 of the 14 cases in this study was not available. CRHD, chronic rheumatic heart disease; CVC, central venous catheter; ESRF, end-stage renal failure; F, female; i.v., intravenous; ICU, intensive care unit; M, male; PVC, peripheral venous catheter; PICC, peripherally inserted central catheter.
b
Duration of intravenous catheter in situ before onset of fungemia.