Fig. 3.

Adenosine reduces the frequency of miniature PSCs (mPSCs) recorded from interneurons. A: voltage-clamp recordings from an interneuron held at −60 mV in the presence of TTX, where sodium currents are blocked and so action potential-independent, mPSCs are isolated. B: averaged cumulative probability plot showing no change in amplitude of miniature postsynaptic potentials (n = 8 cells). C: averaged data showing that application of adenosine has no effect on the amplitude of mPSCs. D: averaged cumulative probability plot showing an increase in the interval between events in the presence of adenosine. E: averaged data showing that application of adenosine causes an increase in the interval between mPSCs. These data support involvement of presynaptic adenosine receptors in adenosine-mediated modulation of synaptic transmission. *Significantly different from control.