Table 1.
Effect of berberine on DNA of L929 cells (n = 50).
| Concentration (mg/mL) | Indicators | |||
|---|---|---|---|---|
| TL (μm) | TDNA (%) | TM (μm) | Olive TM (μm) | |
| 0 | 3.25 ± 0.46 | 0.37 ± 0.25 | 0.01 ± 0.01 | 0.18 ± 0.13 |
| 0.0025 | 8.67 ± 1.80 | 0.27 ± 0.20 | 0.02 ± 0.01 | 0.19 ± 0.11 |
| 0.0125 | 133.4 ± 18.50∗∗ | 11.73 ± 6.13∗∗ | 7.11 ± 3.76 | 6.14 ± 1.96 |
| 0.0250 | 240.1 ± 27.21∗∗ | 26.67 ± 10.55∗∗ | 35.97 ± 15.26∗∗ | 24.50 ± 9.31∗∗ |
| Positive control | 286.3 ± 53.71∗∗ | 84.12 ± 9.95∗∗ | 243.5 ± 64.27∗∗ | 131.88 ± 37.61∗∗ |
Visual scorings of DNA damage were based on the fluorescence intensity. TL: tail length; TDNA: tail DNA%; TM: tail moment; OTM: olive tail moment. Values are expressed as mean ± SD. ∗∗ p < 0.01 compared with the control.