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Illustration of the time-dependent biphasic effect of IFN-γ on the 40 pS K+ channel in RPTECs. Prolonged treatment of cells with IFN-γ greatly enhances iNOS expression, which results in generation of a large amount of NO. The excessive NO reacts with superoxide (O2 −) to form peroxynitrite (ONOO−), which impairs the 40 pS K+ channel by oxidation and/or nitrosylation. IFN-γ also acutely activates the 40 pS K+ channel by unknown mechanisms. IFNGR: IFN-γ receptor.
