Table 4.
Top five toxic lists predicted by IPA that were corresponding to 125 mRNAs of the intersection of the four differentially expressed miRNAs predicted target genes and DEGs under FMT water extract treatment.
Tox lists | -log(p-value) | Molecules |
---|---|---|
Liver necrosis/Cell death | 3.73 | SPTBN1, MNT, ARF6, JUN, ABL2, IGFBP1, SERPINE1, MCL1 |
Cardiac hypertrophy | 3.43 | MNT, EPAS1, JUN, ATF3, HIF1A, MAP3K5, SERPINE1, PRKCA, DYRK1A |
NRF2-mediated oxidative stress response | 3.38 | JUN, CYP2U1, STIP1, JUNB, MAP3K5, ENC1, PRKCA |
Acute renal failure panel | 3.34 | LIFR, JUN, ATF3, IGFBP1 |
RAR activation | 3.26 | TRIM24, JUN, SMARCD2, MAP3K5, PML, PRKCA |