Table 1.

Comparisons of CEST/APT and DTI parameters values in the substantia nigra for Parkinson’s disease (PD) patients and normal controls (mean ± 95% CI).

		Normal (n = 23)	PD (n = 23)	P values
CEST/APT	MTRasym(3.5 ppm)	1.25 ± 0.18	0.89 ± 0.15	0.003
	${\text{MTR}}_{\text{asym}}^{\text{total}}$	3.45 ± 0.44	2.45 ± 0.50	0.004
DTI	FA	0.36 ± 0.02	0.32 ± 0.02	<0.001
	MD	0.68 ± 0.02	0.70 ± 0.03	0.400

MTR_asym(3.5 ppm) was quantified by % water signal intensity. ${\mathit{\text{MTR}}}_{\mathit{\text{asym}}}^{\mathit{\text{total}}}$ was defined as the integral of the MTR_asym spectrum in the range of 0–4 ppm. FA, fractional anisotropy; MD, mean diffusivity. Bold indicates significant change.