Table 5.

Comparisons of CEST/APT and DTI parameters values in the caudate for Parkinson’s disease (PD) patients and normal controls (mean ± 95% CI).

		Normal (n = 23)	PD (n = 23)	P values
CEST/APT	MTRasym(3.5 ppm)	0.84 ± 0.17	1.14 ± 0.14	0.009
	${\text{MTR}}_{\text{asym}}^{\text{total}}$	2.79 ± 0.21	2.90 ± 0.35	0.573
DTI	FA	0.16 ± 0.01	0.15 ± 0.01	0.563
	MD	0.74 ± 0.03	0.75 ± 0.01	0.546

MTR_asym(3.5 ppm) was quantified by % water signal intensity. ${\mathit{\text{MTR}}}_{\mathit{\text{asym}}}^{\mathit{\text{total}}}$ was defined as the integral of the MTR_asym spectrum in the range of 0–4 ppm. FA, fractional anisotropy; MD, mean diffusivity. Bold indicates significant change.