Table 3.

Estimated risk coefficients on univariate analysis for 1444 patients treated in consecutive COG studies.

Factor	Characteristic	Relative risk	95% confidence interval	p value compared reference	Global p value
Age yrs. (ref. <9)					0.0000
	10–17	1.34	1.08–1.66	0.0090
	18+	2.35	1.78–3.11	0.0000
Primary site (ref. pelvis)					0.0002
	Nonpelvic tumor	0.70	0.52–0.93	0.0140
	Extraosseous	0.52	0.37–0.72	0.0000
Gender (ref. male)					0.3404
	Female	0.92	0.77–1.10	0.08
Treatment (ref. standard timing)					0.0002
	Non-I/E	1.65	1.31–2.09	0.0000
	Intensive timing	0.82	0.64–1.06	0.1260
Tumor size, cm (ref. <8)					0.0002
	9–12 cm	1.26	0.96–1.65	0.0990
	>13 cm	1.98	1.45–2.70	0.0000