Table 1.

Clinical trials using placenta-derived cells, fetal membranes, or derivatives in ophthalmic disorders.

Condition	Clinical trial ID	Phase	Materials used	Status	Sponsor	Results/status or remarks
Scleral thinning	NCT00801073	II/III	AM graft	Enrolling	Federal University of São Paulo, Brazil	Primary Completion Date: February 2005, last verified December 2008 (de Farias et al., 2014)
Bullous keratopathy	NCT01926535	II	AM graft	Completed	Universidad de Valparaiso, Chile	None available, Study Completion Date: June 2012
	NCT00659308	ns	AM	Completed	Federal University of São Paulo, Brazil	Study Completion Date: June 2007, last verified January 2008 (Paris Fdos et al., 2013)
Pterygium or ocular surface cicatrizing diseases or keratitis	NCT02102776	ns	AM	Not yet recruiting	Shiyou Zhou, Sun Yat-sen University, China	Estimated Study Completion Date: September 2016
	NCT01319721	ns	AM graft	Completed	Shiyou Zhou, Sun Yat-sen University, China	Results available online (https://clinicaltrials.gov), Study Completion Date: June 2014
	NCT00457223	II/III	AM	Completed	Chulalongkorn University, Thailand	None available, study completed in 2007
	NCT00802620	I	AM	Enrolling	Federal University of São Paulo, Brazil	None available, Primary Completion Date: June 2005, last verified December 2008
	NCT02015000	ns	AM	Recruiting	National Taiwan University Hospital, Taiwan	Estimated Study Completion Date: November 2014, last verified December 2013
	NCT00383825	ns	AM	Completed	Baskent University, Ankara, Turkey	None available, Estimated Study Completion Date: December 2004, last verified October 2006
	NCT00344201	I	AM	Completed	Singapore National Eye Centre, Singapore	None available, Study Completion Date: January 2008
	NCT02116062	ns	AM	Recruiting	University Hospital, Strasbourg, France	Estimated Study Completion Date: March 2016
Corneal wounds or ulcers or epithelial defects	NCT00915759	ns	ProKera®	Active	Walter Reed National Military Medical Center, Washington, DC, USA	Estimated Study Completion Date: December 2014, last verified July 2014
	NCT02168790	0	Amnioclip ring system	Completed	Klinikum Chemnitz gGmbH, Germany	None available, Study Completion Date: August 2013
	NCT00238862	ns	AM	Completed	King Khaled Eye Specialist Hospital, Riyadh, Saudi Arabia	None available, study completed in 2007
	NCT02395952	ns	ProKera®, Ambiodisk	Not yet recruiting	Milton S. Hershey Medical Center, PA, USA	Estimated Primary Completion Date: February 2018
	NCT02148016	I/II	AM	Recruiting	Sun Yat-sen University, China	Estimated Study Completion Date: September 2014, last verified May 2014
Limbal stem cell deficiency	NCT01377311	I	AM	Terminated	National Taiwan University Hospital, Taiwan	Study terminated since technique not used in patients, last verified June 2011
	NCT00736307	I/II	AM	Completed	Royan Institute, Tehran, Iran	None available, Study Completion Date: October 2009, last verified April 2010
	NCT01562002	I/II	AM	Completed	Instituto Universitario de Oftalmobiología Aplicada, Spain	None available, Study Completion Date: December 2014, last verified January 2015
	NCT01619189	II	AM	Ongoing	Centre Hospitalier National d’Ophtalmologie des Quinze-Vingts, France	Primary Completion Date: December 2014, last verified February 2015
	NCT00491959	I	AM	Terminated	National Taiwan University Hospital, Taiwan	Study terminated due to unstable cell sheet quality, thus this technique was not used on patients
Ocular surface disease and reconstruction	NCT00348114	II	AM	Completed	Singapore National Eye Centre, Singapore	This study has suspended participant recruitment since 2006
	NCT01341223	ns	AM	Recruiting	National Taiwan University Hospital, Taiwan	Estimated Primary Completion Date: March 2016, last verified March 2012
Dry eye syndrome	NCT02369861	I	ACCS	Recruiting	Stemnion, Inc., Pittsburgh, PA, USA	Estimated Study Completion Date: December 2015
Glaucoma	NCT01551550	II/III	AM graft	Recruiting	Tissue Tech™ Inc., Miami, FL, USA	Estimated Study Completion Date: August 2015

The search status as of June 2015 registered on the ClinicalTrials.gov site of U.S. National Institutes of Health (https://clinicaltrials.gov).

ns, not specified; AM, amniotic membrane; ACCS, amnion-derived Cellular Cytokine Solution (Stemnion, Inc.); ProKera^® (Tissue Tech™ Inc.) is a device made by a piece of amniotic membrane tissue in between two rings made out of flexible material.