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Leptin-deficient ob/ob mice and hyperleptinemic LoxTB MC4R−/− mice showed increased lipid accumulation (A) and decreased ATP levels (B) in the kidneys. However, only the LoxTB MC4R−/− mice exhibited increased protein carbonyl levels, a measure of oxidative stress, compared with WT-LoxTB control mice (C). Values are means ± SE. *P < 0.05 compared with WT Control. †P < 0.05 compared with WT-LoxTB mice. ‡P < 0.05 compared with LoxTB MC4R−/− mice.
