Table 2.

Metabolic and cardiovascular parameters of transgenic and wild-type mice

Parameter	WT (n = 7)	ob/ob (n = 7)	WT-LoxTB (n = 7)	LoxTB MC4R−/− (n = 7)
Plasma leptin, ng/ml	4.9 ± 2.1	Undetectable	7.8 ± 3.0	49.1 ± 9.8
Plasma insulin, μU/ml	6.8 ± 1.9	100.1 ± 16.1*	8.2 ± 1	63.5 ± 12.3†
Fasting blood glucose, mg/dl	110 ± 5	198 ± 14*‡	113 ± 7	150 ± 10†
Mean arterial pressure, mmHg	111 ± 1	111 ± 1	111 ± 1	110 ± 9
Heart rate, beats/min	557 ± 7	569 ± 12	538 ± 4	555 ± 48

Values are means ± SE.

^*P < 0.05 compared with WT.

^†P < 0.05 compared with WT-LoxTB.

^‡P < 0.05 compared with LoxTB MC4R−/−.