Table 1.
Summary of published studies documenting obesity or hepatic lipid phenotypes in L-Fabp−/− mouse lines
| Authors | Ref. No. | KO Line | Sex | Age | Diet | Background | Control | KO Phenotype |
|---|---|---|---|---|---|---|---|---|
| Studies showing increased obesity or hepatic lipid | ||||||||
| Martin et al.,J Biol Chem, 2003 | 22 | Fabp1tm1Bin | F | 13–15 mo | Chow | Mixed | Littermate | Increased liver chol, CE, PL |
| Martin et al., Biochemistry, 2003 | 23 | Fabp1tm1Bin | F | 13–15 mo | Chow | Mixed | Littermate | Increased liver CE, PL; decreased liver TG |
| Martin et al., Am J Physiol Gastrointest Liver Physiol, 2006 | 18 | Fabp1tm1Bin | F | 7–12 wk | 1.25% Chol/control | Mixed | Littermate | Increased BW on control and chol. Increased liver chol |
| Martin et al., Mol Cell Biochem, 2009 | 21 | Fabp1tm1Bin | M | 3–18 mo | Chow | N6 to C57BL/6? | C57BL/6? | Increased BW by 9 mo; liver TG decreased at 3 mo, not 18 mo |
| Martin et al., J Nutr, 2008 | 19 | Fabp1tm1Bin | F | 3–18 mo | Chow | N6/C57BL/6? | C57BL/6? | Increased BW by 9 mo; liver TG decreased at 3 mo, not 18 mo |
| Martin et al., Am J Physiol Gastrointest Liver Physiol, 2009 | 17 | Fabp1tm1Bin | Both | >8 mo | Chow | From N2 to N10 to C57BL/6NCr | Littermate | Increased liver chol in F; Decreased liver TG in M |
| Atshaves et al., Lipids, 2010 | 3 | Fabp1tm1Bin | Both | 7–20 wk | Control, HFD, pair fed | N6 C57Bl/6NCr | C57BL/6NCr | Increased BW in HFD-fed F; no Δ in M. No Δ in liver TG |
| McIntosh et al., Lipids, 2013 | 24 | Fabp1tm1Bin | F | 8–20 wk | Control, HFD | N11 C57Bl/6NCr | C57BL/6NCr | Increased BW on HFD, not control |
| Gajda et al., J Biol Chem, 2013 | 12 | Fabp1tm1Bin | M | 8–20 wk | High SF, UF diets | N6 C57BL/6J | C57BL/6J | Increased BW and weight gain on both HFD |
| Studies showing decreased/unchanged obesity or hepatic lipid | ||||||||
| Newberry et al., J Biol Chem, 2003 | 29 | Fabp1tm1Ddsn | M | 2–4 mo | Chow, fasted | Mixed | Littermate | Decreased liver TG after fasting |
| Atshaves et al., J Biol Chem, 2004 | 4 | Fabp1tm1Bin | M | 2–4 mo | Chow, AIN76A | Mixed | Littermate | Decreased liver TG, FA, total lipid |
| Atshaves et al., Am J Physiol Cell Physiol, 2005 | 2 | Fabp1tm1Bin | Both | 2 mo | Chow, phytanic acid | Mixed | Littermate | Decreased liver TG in M |
| Martin et al., Biochem J, 2005 | 20 | Fabp1tm1Bin | M | 7–12 wk | 1.25% Chol/control | Mixed | Littermate | No Δ in BW; liver TG decreased on control diet |
| Newberry et al., Hepatology, 2006 | 30 | Fabp1tm1Ddsn | F | 12–30 wk | Western HFD | N5 to C57BL/6J | C57BL/6J | Decreased BW on HFD. Decreased liver TG |
| Newberry et al., Am J Physiol Gastrointest Liver Physiol, 2008 | 28 | Fabp1tm1Ddsn | F | 2–8 mo | 1.25% Chol, SF, and PUFA | N8 to C57BL/6J | C57BL/6J | Decreased obesity/liver TG on SF and chol, but not PUFA diet |
| Newberry et al., Mol Cell Biochem, 2009 | 27 | Fabp1tm1Ddsn | F | 10–24 wk | High chol, SF, and Western | N7 to C57BL/6J | C57BL/6J | Reduced weight gain on HF and chol diets |
| Lagakos et al., Am J Physiol Gastrointest Liver Physiol, 2011 | 15 | Fabp1tm1Bin | M | 0–5 mo | Chow | N6 C57BL/6J | Littermate | No difference in BW at 5 mo |
| Newberry et al., J Lipid Res, 2012 | 26 | Fabp1tm1Ddsn | F | 3–13 mo | Chow | N7 to C57BL/6J | C57BL/6J | Reduced BW by 5 mo; liver TG lower at 3 and 13 mo |
| Chen et al., Hepatology, 2013 | 7 | Fabp1tm1Ddsn | F | 8–20 | HF, high fructose | N8–9 to C57BL/6J | C57BL/6J | Reduced hepatic TG |
KO, knockout; F, female; M, male; HFD, high-fat diet (fat source not indicated); SF, high-saturated fat diet; UF, unsaturated fat diet; chol, cholesterol; CE, cholesterol ester; PL, phospholipid; TG, triglyceride; BW, body weight; Δ, change; chow, rodent chow diet; FA, fatty acid; PUFA, high polyunsaturated fat diet. “C57BL/6?” indicates that the specific substrain was not reported.