Table 5.
Characterization of high-SF diet-fed mice
| C57BL/6J | NJ L-Fabp−/− | WU L-Fabp−/− | |
|---|---|---|---|
| Initial BW, g | 19.5 ± 0.4 (9) | 20.6 ± 0.4 (15) | 19.7 ± 0.4 (11) |
| Final BW, g | 28.8 ± 1.3a (9) | 26.4 ± 0.9a (15) | 24.3 ± 0.9b (11) |
| Weight gain, g | 9.4 ± 1.0a (9) | 5.8 ± 0.7b (15) | 4.6 ± 0.6b (11) |
| Liver, g | 1.6 ± 0.1a (9) | 1.3 ± 0.1b (15) | 1.2 ± 0.1b (11) |
| Liver/body, % | 5.5 ± 0.2a (9) | 4.9 ± 0.2b (15) | 5.0 ± 0.2b (11) |
| Fat weight, g | 1.0 ± 0.2 (9) | 0.8 ± 0.1 (15) | 0.5 ± 0.1 (11) |
| Fat/body, % | 3.3 ± 0.4 (9) | 3.0 ± 0.3 (15) | 2.2 ± 0.3 (11) |
| Food consumed, g/day | 3.34 ± 0.1a (9) | 2.91 ± 0.05b (15) | 3.11 ± 0.13a,b (9) |
| Fat absorption, % | 98.8 ± 0.1 (5) | 98.5 ± 0.1 (5) | 98.6 ± 0.1 (5) |
| Serum | |||
| TG, mg/dl | 18.3 ± 3.8 (9) | 17.8 ± 3.2 (10) | 11.6 ± 0.8 (7) |
| Chol, mg/dl | 67.4 ± 2.0 (9) | 70.4 ± 2.6 (10) | 77.7 ± 7.5 (7) |
| FFA, mmol/l | 0.77 ± 0.04 (9) | 0.80 ± 0.06 (10) | 0.67 ± 0.03 (7) |
| Glucose, mg/dl | 382 ± 15a (9) | 302 ± 31a (10) | 251 ± 20b (7) |
| Insulin, pg/ml | 69.5 ± 14 (6) | 95.8 ± 24 (6) | 95.0 ± 13.4 (5) |
| Hepatic lipid | |||
| TG, μg/mg | 466 ± 28a (9) | 388 ± 33a (10) | 221 ± 16b (9) |
| Chol, μg/mg | 35.7 ± 1.5 (9) | 36.9 ± 3.2 (10) | 30.5 ± 2.4 (9) |
| FFA, nmol/mg | 107.4 ± 4.0a (9) | 96.2 ± 3.1a (10) | 85.2 ± 2.9a,b (9) |
| PL, μg/mg | 103.2 ± 9.2 (9) | 87.7 ± 9.0 (10) | 94.3 ± 5.9 (9) |
| Intestinal lipid | |||
| TG, μg/mg | 267 ± 33 (5) | 354 ± 90 (6) | 335 ± 87 (5) |
| Chol, μg/mg | 22.4 ± 1.8 (5) | 24.3 ± 3.9 (6) | 25.8 ± 4.1 (5) |
| FFA, nmol/mg | 190 ± 18a (5) | 232 ± 31a,b (6) | 183 ± 32a (5) |
Values are means ± SE; nos. in parentheses, no. animals studied for each parameter. a,bDifferent superscript letters indicate a significant difference between the groups: P < 0.05.