Table 2.
CPA2 variants identified in Japanese patients with CP
|
P Value |
||||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Exon | Nucleotide Change | Amino Acid Change | Genotype | All CP (%) | NACP (%) | ACP (%) | HGVD (%) | All CP | NACP | ACP |
| Nonsynonymous | ||||||||||
| 6 | c.504C>G | p.D168E | CG | 1/477 (0.2) | 1/243 (0.4) | 0/234 (0) | 1/373 (0.3) | 1.00 | 1.00 | 1.00 |
| 8 | c.709C>T | p.R237W | CT | 19/477 (4.0) | 9/243 (3.7) | 10/234 (4.3) | 23/673 (3.4) | 0.63 | 0.84 | 0.55 |
| 11 | c.1162G>A | p.G388S | GA | 1/477 (0.2) | 1/243 (0.4) | 0/234 (0) | 0/673 (0) | 0.41 | 0.27 | 1.00 |
| Synonymous | ||||||||||
| 7 | c.633T>C | p.D211= | TC | 159/477 (33.3) | 71/243 (29.2) | 88/234 (37.6) | 417/1208 (34.5) | 0.75 | 0.28 | 0.42 |
| CC | 291/477 (61.0) | 159/243 (65.4) | 132/234 (56.4) | 732/1208 (60.6) | ||||||
| 9 | c.828C>T | p.H276= | CT | 5/477 (1.0) | 2/243 (0.8) | 3/234 (1.3) | 17/747 (2.3) | 0.13 | 0.19 | 0.44 |
| 11 | c.1161C>T | p.Y387= | CT | 5/477 (1.0) | 1/243 (0.4) | 4/234 (1.7) | 19/1140 (1.7) | 0.50 | 0.23 | 1.00 |
CP, chronic pancreatitis; NACP, nonalcoholic CP; ACP, alcoholic CP; HGVD, Human Genetic Variation Database. P values were determined between HGVD and all CP, NACP, or ACP by the Fisher's exact test.